David Rodrigues da Rocha
Overview
Explore the profile of David Rodrigues da Rocha including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
22
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0
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Recent Articles
1.
Cesar Cirne-Santos C, Gomes Gonzaga D, Oliveira de Resende G, Goncalves M, Andrade A, Furtado Pacheco P, et al.
Curr Top Med Chem
. 2025 Jan;
PMID: 39844553
Background: Zika (ZIKV) is a virus transmitted by mosquitoes that can cause Guillain- Barré syndrome and congenital malformations like microcephaly. Given its explosive resurgence and the resulting epidemics in 2016,...
2.
Santos T, de Moraes L, Furtado Pacheco P, Dos Santos D, Ribeiro R, Moreira C, et al.
Pharmaceuticals (Basel)
. 2023 Nov;
16(11).
PMID: 38004442
Parkinson's disease (PD) is a degenerative disease that affects approximately 6.1 million people and is primarily caused by the loss of dopaminergic neurons. Naphthoquinones have several biological activities explored in...
3.
Furtado Pacheco P, Faria J, Silva A, von Ranke N, Silva R, Rodrigues C, et al.
Biomed Pharmacother
. 2023 Apr;
162:114608.
PMID: 37003033
Purinergic receptors are transmembrane proteins responsive to extracellular nucleotides and are expressed by several cell types throughout the human body. Among all identified subtypes, the P2×7 receptor has emerged as...
4.
Furtado Pacheco P, Gomes Gonzaga D, von Ranke N, Rodrigues C, da Rocha D, de Carvalho da Silva F, et al.
Molecules
. 2023 Jan;
28(2).
PMID: 36677652
ATP acts in the extracellular environment as an important signal, activating a family of receptors called purinergic receptors. In recent years, interest in the potential therapeutics of purinergic components, including...
5.
da Silva E, Mesquita F, Ramos I, Gomes C, Moreira C, Ferreira V, et al.
Toxicol Appl Pharmacol
. 2022 Oct;
456:116256.
PMID: 36208702
Colorectal cancer (CRC) is estimated as the third most incident cancer and second in mortality worldwide. Moreover, CRC metastasis reduces patients' survival rates. Thus, the study and identification of new...
6.
Jullyanne de Sousa Portilho A, da Silva E, Cintra Austregesilo Bezerra E, Gomes C, Ferreira V, de Moraes M, et al.
Int J Mol Sci
. 2022 Jul;
23(15).
PMID: 35897681
The multidrug resistance (MDR) phenotype is one of the major obstacles in the treatment of chronic myeloid leukemia (CML) in advantage stages such as blast crisis. In this scenario, more...
7.
Guilhon-Simplicio F, Serrao C, da Silva Pinto A, Furtado Pacheco P, Xavier Faria R, da Rocha D, et al.
Chem Biol Drug Des
. 2022 Mar;
99(6):868-883.
PMID: 35313075
Triterpenes α,β-amyrin are naturally occurring molecules that can serve as building blocks for synthesizing new chemical entities. This study synthesized acyl, carboxyesther, NSAID, and nitrogenous derivatives and evaluated their antimicrobial...
8.
Furtado Pacheco P, de Menezes Ribeiro T, Dos Santos Galvao R, Dos Santos E, Faria A, von Ranke N, et al.
J Bioenerg Biomembr
. 2020 May;
52(3):199-213.
PMID: 32418003
A series of 11 new N,S-acetal juglone derivatives were synthesized and evaluated against T. cruzi epimastigote forms. These compounds were obtained in good to moderate yields using a microwave irradiation...
9.
Evaluation of 5-hydroxy-1,4-naphthoquinone-cobalt(III) complexes for hypoxia-activated drug delivery
de Mello M, Cebrian-Torrejon G, Pereira J, Moreira C, Gomes C, da Rocha D, et al.
J Inorg Biochem
. 2019 Jul;
199:110756.
PMID: 31299378
Three novel PyNcobalt(III) complexes with the 5-hydroxy-1,4-naphthoquinone nuclei (NQ) were evaluated as potential hypoxia-activated anticancer prodrugs. The complexes were synthesized and fully characterized by IR and UV-Visible spectroscopies, ESI mass...
10.
Sodero A, Abrahim-Vieira B, Monteiro Torres P, Pascutti P, Garcia C, Ferreira V, et al.
Mem Inst Oswaldo Cruz
. 2017 Mar;
112(4):299-308.
PMID: 28327793
Background: Malaria persists as a major public health problem. Atovaquone is a drug that inhibits the respiratory chain of Plasmodium falciparum, but with serious limitations like known resistance, low bioavailability...