David R McGivern
Overview
Explore the profile of David R McGivern including associated specialties, affiliations and a list of published articles.
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Articles
41
Citations
1325
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0
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Recent Articles
21.
McGivern D, Masaki T, Lovell W, Hamlett C, Saalau-Bethell S, Graham B
J Virol
. 2015 Mar;
89(10):5362-70.
PMID: 25740995
Unlabelled: Hepatitis C virus (HCV) NS3 is a multifunctional protein composed of a protease domain and a helicase domain linked by a flexible linker. Protease activity is required to generate...
22.
Masaki T, Arend K, Li Y, Yamane D, McGivern D, Kato T, et al.
Cell Host Microbe
. 2015 Feb;
17(2):217-28.
PMID: 25662750
The liver-specific microRNA, miR-122, stabilizes hepatitis C virus (HCV) RNA genomes by recruiting host argonaute 2 (AGO2) to the 5' end and preventing decay mediated by exonuclease Xrn1. However, HCV...
23.
Yamane D, McGivern D, Wauthier E, Yi M, Madden V, Welsch C, et al.
Nat Med
. 2014 Jul;
20(8):927-35.
PMID: 25064127
Oxidative tissue injury often accompanies viral infection, yet there is little understanding of how it influences virus replication. We show that multiple hepatitis C virus (HCV) genotypes are exquisitely sensitive...
24.
McGivern D, Masaki T, Williford S, Ingravallo P, Feng Z, Lahser F, et al.
Gastroenterology
. 2014 Apr;
147(2):453-62.e7.
PMID: 24768676
Background & Aims: All-oral regimens combining different classes of direct-acting antivirals (DAA) are highly effective for treatment of patients with chronic hepatitis C. NS5A inhibitors will likely form a component...
25.
Dansako H, Yamane D, Welsch C, McGivern D, Hu F, Kato N, et al.
PLoS Pathog
. 2013 May;
9(5):e1003345.
PMID: 23717201
Persistent infections with hepatitis C virus (HCV) may result in life-threatening liver disease, including cirrhosis and cancer, and impose an important burden on human health. Understanding how the virus is...
26.
Yamane D, McGivern D, Masaki T, Lemon S
Curr Top Microbiol Immunol
. 2013 Mar;
369:263-88.
PMID: 23463205
Chronic hepatitis C virus (HCV) infection is a leading cause of liver-specific morbidity and mortality in humans, including progressive liver fibrosis, cirrhosis, and hepatocellular carcinoma. It has also been associated...
27.
Li Y, Masaki T, Yamane D, McGivern D, Lemon S
Proc Natl Acad Sci U S A
. 2012 Dec;
110(5):1881-6.
PMID: 23248316
Hepatitis C virus (HCV) replication is dependent on microRNA 122 (miR-122), a liver-specific microRNA that recruits Argonaute 2 to the 5' end of the viral genome, stabilizing it and slowing...
28.
Lemon S, McGivern D
Gastroenterology
. 2012 Apr;
142(6):1274-8.
PMID: 22537433
No abstract available.
29.
McGivern D, Lemon S
Gastroenterology
. 2011 Jul;
141(3):806-9.
PMID: 21791207
No abstract available.
30.
Kannan R, Hensley L, Evers L, Lemon S, McGivern D
J Virol
. 2011 Jun;
85(16):7989-8001.
PMID: 21680513
Chronic infection with the hepatitis C virus (HCV) is associated with increased risk for hepatocellular carcinoma (HCC). Chronic immune-mediated inflammation is likely to be an important factor in the development...