Jonathan K Mitchell
Overview
Explore the profile of Jonathan K Mitchell including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
114
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0
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Recent Articles
1.
McKnight K, Swanson K, Austgen K, Richards C, Mitchell J, McGivern D, et al.
Proc Natl Acad Sci U S A
. 2020 Oct;
117(44):27598-27607.
PMID: 33060297
Human rhinoviruses (RVs) are positive-strand RNA viruses that cause respiratory tract disease in children and adults. Here we show that the innate immune signaling protein STING is required for efficient...
2.
Mitchell J, McGivern D
Hepat Oncol
. 2018 Sep;
1(3):293-307.
PMID: 30190964
Infection with hepatitis C virus (HCV) is a major risk factor for hepatocellular carcinoma. The genetic changes that drive cancer development are heterogeneous and how chronic hepatitis C promotes the...
3.
Mitchell J, Midkiff B, Israelow B, Evans M, Lanford R, Walker C, et al.
mBio
. 2017 Apr;
8(2).
PMID: 28442604
Many DNA tumor viruses promote cellular transformation by inactivating the critically important tumor suppressor protein p53. In contrast, it is not known whether p53 function is disrupted by hepatitis C...
4.
Mitchell J, Lemon S, McGivern D
Curr Opin Virol
. 2015 Oct;
14:101-8.
PMID: 26426687
Persistent infection with hepatitis C virus (HCV) is associated with an increased risk of hepatocellular carcinoma (HCC). Cancer typically develops in a setting of chronic hepatic inflammation and advanced fibrosis...
5.
Vandergaast R, Mitchell J, Byers N, Friesen P
J Virol
. 2015 Feb;
89(8):4481-93.
PMID: 25653450
Unlabelled: Inhibitor-of-apoptosis (IAP) proteins are key regulators of the innate antiviral response by virtue of their capacity to respond to signals affecting cell survival. In insects, wherein the host IAP...
6.
Mitchell J, Byers N, Friesen P
J Virol
. 2013 Sep;
87(23):12592-9.
PMID: 24027328
The DNA damage response (DDR) of a host organism represents an effective antiviral defense that is frequently manipulated and exploited by viruses to promote multiplication. We report here that the...
7.
Mitchell J, Friesen P
J Virol
. 2012 Oct;
86(24):13542-53.
PMID: 23035220
The baculovirus Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) initiates apoptosis in diverse insects through events triggered by virus DNA (vDNA) replication. To define the proapoptotic pathway and its role in antivirus...
8.
Taggart D, Mitchell J, Friesen P
J Virol
. 2012 Apr;
86(12):6575-85.
PMID: 22496221
IE1 is the principal transcriptional regulator of the baculoviruses. Like multifunctional transcription factors of other large DNA viruses, IE1 is an essential, site-specific DNA-binding phosphoprotein that activates virus gene expression...