David R McGivern
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Explore the profile of David R McGivern including associated specialties, affiliations and a list of published articles.
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41
Citations
1325
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Recent Articles
11.
Mitchell J, McGivern D
Hepat Oncol
. 2018 Sep;
1(3):293-307.
PMID: 30190964
Infection with hepatitis C virus (HCV) is a major risk factor for hepatocellular carcinoma. The genetic changes that drive cancer development are heterogeneous and how chronic hepatitis C promotes the...
12.
Zhou S, Williford S, McGivern D, Burch C, Hu F, Benzine T, et al.
Antiviral Res
. 2018 Aug;
158:45-51.
PMID: 30081054
Direct-acting antivirals (DAAs) targeting NS5A are broadly effective against hepatitis C virus (HCV) infections, but sustained virological response rates are generally lower in patients infected with genotype (gt)-1a than gt-1b...
13.
Parr J, Lodge E, Holzmayer V, Pepin J, Frost E, Fried M, et al.
Clin Infect Dis
. 2017 Oct;
66(2):254-260.
PMID: 29048459
Background: Efficient viral load testing is needed for hepatitis C (HCV) surveillance and diagnosis. HCV viral load testing using dried blood spots (DBSs), made with a single drop of finger-prick...
14.
Feng H, Lenarcic E, Yamane D, Wauthier E, Mo J, Guo H, et al.
Nat Immunol
. 2017 Oct;
18(12):1299-1309.
PMID: 28967880
NLRX1 is unique among the nucleotide-binding-domain and leucine-rich-repeat (NLR) proteins in its mitochondrial localization and ability to negatively regulate antiviral innate immunity dependent on the adaptors MAVS and STING. However,...
15.
Benzine T, Brandt R, Lovell W, Yamane D, Neddermann P, De Francesco R, et al.
PLoS Pathog
. 2017 Jun;
13(6):e1006343.
PMID: 28594932
Hepatitis C virus (HCV) RNA is synthesized by the replicase complex (RC), a macromolecular assembly composed of viral non-structural proteins and cellular co-factors. Inhibitors of the HCV NS5A protein block...
16.
Mitchell J, Midkiff B, Israelow B, Evans M, Lanford R, Walker C, et al.
mBio
. 2017 Apr;
8(2).
PMID: 28442604
Many DNA tumor viruses promote cellular transformation by inactivating the critically important tumor suppressor protein p53. In contrast, it is not known whether p53 function is disrupted by hepatitis C...
17.
Chronic hepatitis C infection-induced liver fibrogenesis is associated with M2 macrophage activation
Bility M, Nio K, Li F, McGivern D, Lemon S, Feeney E, et al.
Sci Rep
. 2016 Dec;
6:39520.
PMID: 28000758
The immuno-pathogenic mechanisms of chronic hepatitis C virus (HCV) infection remain to be elucidated and pose a major hurdle in treating or preventing chronic HCV-induced advanced liver diseases such as...
18.
Hirai-Yuki A, Hensley L, McGivern D, Gonzalez-Lopez O, Das A, Feng H, et al.
Science
. 2016 Sep;
353(6307):1541-1545.
PMID: 27633528
Hepatotropic viruses are important causes of human disease, but the intrahepatic immune response to hepatitis viruses is poorly understood because of a lack of tractable small- animal models. We describe...
19.
Mitchell J, Lemon S, McGivern D
Curr Opin Virol
. 2015 Oct;
14:101-8.
PMID: 26426687
Persistent infection with hepatitis C virus (HCV) is associated with an increased risk of hepatocellular carcinoma (HCC). Cancer typically develops in a setting of chronic hepatic inflammation and advanced fibrosis...
20.
Wang Y, McGivern D, Cheng L, Li G, Lemon S, Niu J, et al.
PLoS One
. 2015 Aug;
10(8):e0135232.
PMID: 26274905
Ribavirin is used as a component of combination therapies for the treatment of chronic hepatitis C virus (HCV) infection together with pegylated interferon and/or direct-acting antiviral drugs. Its mechanism of...