David R McGivern
Overview
Explore the profile of David R McGivern including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
41
Citations
1325
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Subramaniam S, Fares-Gusmao R, McGivern D
Viruses
. 2024 Mar;
16(3).
PMID: 38543759
Hepatitis E virus (HEV) causes acute hepatitis in humans, which can progress to chronicity in immunosuppressed individuals. Almost all reported HEV infections are caused by genotypes 1-4. The structural ORF2...
2.
Subramaniam S, Fares-Gusmao R, Sato S, Cullen J, Takeda K, Farci P, et al.
PLoS Pathog
. 2023 Sep;
19(9):e1011664.
PMID: 37703304
Hepatitis E virus (HEV) causes self-limited acute hepatitis in immunocompetent individuals and can establish chronic infection in solid organ transplant recipients taking immunosuppressive drugs. A well characterized small animal model...
3.
Fares-Gusmao R, Jiang Z, Subramaniam S, Visser B, Scott A, Ishida Y, et al.
J Clin Virol
. 2022 Nov;
157:105325.
PMID: 36395548
Background: To harmonize assays for detection of HEV RNA, a World Health Organization International Standard (WHO IS) was established. The WHO IS represents the highest order standard for HEV RNA...
4.
Shiota T, Matsuda M, Zheng X, Nagata N, Ishii K, Suzuki R, et al.
J Virol
. 2022 Nov;
96(23):e0149622.
PMID: 36354341
Although hepatitis A virus (HAV) is associated only with acute hepatitis in humans, HAV RNA persists within the liver for months following resolution of liver inflammation and cessation of fecal...
5.
Li Y, Misumi I, Shiota T, Sun L, Lenarcic E, Kim H, et al.
Proc Natl Acad Sci U S A
. 2022 Jul;
119(28):e2204511119.
PMID: 35867748
Despite excellent vaccines, resurgent outbreaks of hepatitis A have caused thousands of hospitalizations and hundreds of deaths within the United States in recent years. There is no effective antiviral therapy...
6.
Sun L, Li Y, Misumi I, Gonzalez-Lopez O, Hensley L, Cullen J, et al.
PLoS Pathog
. 2021 Sep;
17(9):e1009960.
PMID: 34591933
HAV-infected Ifnar1-/- mice recapitulate many of the cardinal features of hepatitis A in humans, including serum alanine aminotransferase (ALT) elevation, hepatocellular apoptosis, and liver inflammation. Previous studies implicate MAVS-IRF3 signaling...
7.
Nishimura N, De Battista D, McGivern D, Engle R, Tice A, Fares-Gusmao R, et al.
Proc Natl Acad Sci U S A
. 2021 Apr;
118(17).
PMID: 33888584
Older age at the time of infection with hepatitis viruses is associated with an increased risk of liver fibrosis progression. We hypothesized that the pace of fibrosis progression may reflect...
8.
McKnight K, Swanson K, Austgen K, Richards C, Mitchell J, McGivern D, et al.
Proc Natl Acad Sci U S A
. 2020 Oct;
117(44):27598-27607.
PMID: 33060297
Human rhinoviruses (RVs) are positive-strand RNA viruses that cause respiratory tract disease in children and adults. Here we show that the innate immune signaling protein STING is required for efficient...
9.
McGivern D, Lin H, Wang J, Benzine T, Janssen H, Khalili M, et al.
Open Forum Infect Dis
. 2019 May;
6(5):ofz175.
PMID: 31139669
Background: Patients with chronic hepatitis B virus (HBV) may experience spontaneous biochemical flares of liver disease activity. This study aimed to determine (i) the prevalence of prior and possible acute...
10.
Doncheva N, Domingues F, McGivern D, Shimakami T, Zeuzem S, Lengauer T, et al.
J Mol Biol
. 2019 May;
431(12):2354-2368.
PMID: 31051172
A variety of amino acid substitutions in the NS3-4A protease of the hepatitis C virus lead to protease inhibitor (PI) resistance. Many of these significantly impair the replication fitness of...