David R Langley
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Explore the profile of David R Langley including associated specialties, affiliations and a list of published articles.
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54
Citations
1986
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Recent Articles
1.
Abramyan A, Bochicchio A, Wu C, Damm W, Langley D, Shivakumar D, et al.
J Chem Inf Model
. 2025 Jan;
65(3):1392-1403.
PMID: 39883536
Accurate prediction of the affinity of ligand binding to nucleic acids represents a formidable challenge for current computational approaches. This limitation has hindered the use of computational methods to develop...
2.
Gough S, Flanagan J, Teh J, Andreoli M, Rousseau E, Pannone M, et al.
Clin Cancer Res
. 2024 May;
30(16):3549-3563.
PMID: 38819400
Purpose: Estrogen receptor (ER) alpha signaling is a known driver of ER-positive (ER+)/human epidermal growth factor receptor 2 negative (HER2-) breast cancer. Combining endocrine therapy (ET) such as fulvestrant with...
3.
Hickey C, Digianantonio K, Zimmermann K, Harbin A, Quinn C, Patel A, et al.
Nat Struct Mol Biol
. 2024 Jan;
31(2):311-322.
PMID: 38177675
Targeted protein degradation (TPD) by PROTAC (proteolysis-targeting chimera) and molecular glue small molecules is an emerging therapeutic strategy. To expand the roster of E3 ligases that can be utilized for...
4.
Ma C, Chung D, Abramson D, Langley D, Thayer K
ACS Omega
. 2022 Sep;
7(34):29587-29597.
PMID: 36061715
Glutathione peroxidase 4 (GPX4) reduces lipid hydroperoxides in lipid membranes, effectively inhibiting iron-dependent cell death or ferroptosis. The upregulation of the enzyme by the mutations at residues D21 and D23...
5.
Bekes M, Langley D, Crews C
Nat Rev Drug Discov
. 2022 Jan;
21(3):181-200.
PMID: 35042991
Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules. In the...
6.
Sivaprakasam P, Mcdonald I, Iwuagwu C, Chowdari N, Peese K, Langley D, et al.
ACS Med Chem Lett
. 2021 Mar;
12(3):404-412.
PMID: 33738068
A new series with the tetrahydroisoquinoline-fused benzodiazepine (TBD) ring system combined with the surrogates of (1-methyl-1-pyrrol-3-yl)benzene ("MPB") payloads were designed and executed for conjugation with a monoclonal antibody for anticancer...
7.
Chowdari N, Zhang Y, Mcdonald I, Johnson W, Langley D, Sivaprakasam P, et al.
J Med Chem
. 2020 Nov;
63(22):13913-13950.
PMID: 33155811
A series of tetrahydroisoquinoline-based benzodiazepine dimers were synthesized and tested for in vitro cytotoxicity against a panel of cancer cell lines. Structure-activity relationship investigation of various spacers guided by molecular...
8.
Sivaprakasam P, Wang Z, Meanwell N, Khan J, Langley D, Johnson S, et al.
Bioorg Med Chem Lett
. 2020 Sep;
30(22):127531.
PMID: 32890685
Previous studies have identified a series of imidazo[1,2-a]pyridine (IZP) derivatives as potent allosteric inhibitors of HIV-1 integrase (ALLINIs) and virus infection in cell culture. However, IZPs were also found to...
9.
Li G, Meanwell N, Krystal M, Langley D, Naidu B, Sivaprakasam P, et al.
J Med Chem
. 2020 Feb;
63(5):2620-2637.
PMID: 32081010
The standard of care for HIV-1 infection, highly active antiretroviral therapy (HAART), combines two or more drugs from at least two classes. Even with the success of HAART, new drugs...
10.
Peese K, Naidu B, Patel M, Li C, Langley D, Terry B, et al.
Bioorg Med Chem Lett
. 2019 Nov;
30(3):126784.
PMID: 31761656
A series of heterocyclic pyrimidinedione-based HIV-1 integrase inhibitors was prepared and screened for activity against purified integrase enzyme and/or viruses modified with the following mutations within integrase: Q148R, Q148H/G140S and...