David P de Souza
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Explore the profile of David P de Souza including associated specialties, affiliations and a list of published articles.
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61
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1161
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Recent Articles
1.
Bond S, King E, Walker S, Yang C, Liu Y, Liu K, et al.
Nat Commun
. 2025 Mar;
16(1):2338.
PMID: 40057508
During mitochondrial damage, information is relayed between the mitochondria and nucleus to coordinate precise responses to preserve cellular health. One such pathway is the mitochondrial integrated stress response (mtISR), which...
2.
Bezawork-Geleta A, Devereux C, Keenan S, Lou J, Cho E, Nie S, et al.
Nat Commun
. 2025 Mar;
16(1):2135.
PMID: 40032835
Membrane contact sites between organelles are critical for the transfer of biomolecules. Lipid droplets store fatty acids and form contacts with mitochondria, which regulate fatty acid oxidation and adenosine triphosphate...
3.
Chan W, Sakamoto R, Doering T, Narayana V, de Souza D, McConville M, et al.
Environ Microbiol
. 2025 Jan;
27(1):e70011.
PMID: 39838803
Symbiotic cnidarians, such as sea anemones and corals, rely on their mutualistic microalgal partners (Symbiodiniaceae) for survival. Marine heatwaves can disrupt this partnership, and it has been proposed that introducing...
4.
Zhao X, Han M, Yan Q, Yue Y, Ye K, Zhang Y, et al.
Cell Death Dis
. 2025 Jan;
16(1):16.
PMID: 39809754
Mitochondrial oxidative phosphorylation (OXPHOS) is a therapeutic vulnerability in glycolysis-deficient cancers. Here we show that inhibiting OXPHOS similarly suppresses the proliferation and tumorigenicity of glycolytically competent colorectal cancer (CRC) cells...
5.
Tye H, Conos S, Djajawi T, Gottschalk T, Abdoulkader N, Kong I, et al.
Life Sci Alliance
. 2024 Nov;
8(1).
PMID: 39532538
Cell death frequently occurs in the pathogenesis of obesity and metabolic dysfunction-associated fatty liver disease (MAFLD). However, the exact contribution of core cell death machinery to disease manifestations remains ill-defined....
6.
Uren R, Ritchie M, Wong A, Ludeman J, Uno E, Narayana V, et al.
bioRxiv
. 2024 Oct;
PMID: 39463966
Apoptotic cell death is regulated by the BCL-2 protein family, with clusters of BAK or BAX homodimers driving pore formation in the mitochondrial outer membrane via a poorly understood process....
7.
Klose S, de Souza D, Devlin J, Bushell R, Browning G, Vaz P
mSystems
. 2024 Sep;
9(10):e0085224.
PMID: 39315777
Coinfections are known to play an important role in disease progression and severity. Coinfections are common in cats, but no coinfection studies have investigated the dynamics between feline viral and...
8.
Tham Y, Bernardo B, Claridge B, Yildiz G, Woon L, Bond S, et al.
Nat Cardiovasc Res
. 2024 Aug;
2(3):268-289.
PMID: 39196021
Dysregulation of estrogen receptor alpha (ERα) has been linked with increased metabolic and cardiovascular disease risk. Here, we generate and characterize cardiomyocyte-specific ERα knockout (ERαHKO) mice to assess the role...
9.
Bezawork-Geleta A, Moujalled D, de Souza D, Narayana V, Dimou J, Luwor R, et al.
Metabolites
. 2024 Aug;
14(8).
PMID: 39195509
Glioblastoma (IDH-wildtype) represents a formidable challenge in oncology, lacking effective chemotherapeutic or biological interventions. The metabolic reprogramming of cancer cells is a hallmark of tumor progression and drug resistance, yet...
10.
Gubser P, Wijesinghe S, Heyden L, Gabriel S, de Souza D, Hess C, et al.
Cell Rep
. 2024 Aug;
43(8):114632.
PMID: 39159042
Tumor cells undergo uncontrolled proliferation driven by enhanced anabolic metabolism including glycolysis and glutaminolysis. Targeting these pathways to inhibit cancer growth is a strategy for cancer treatment. Critically, however, tumor-responsive...