David Millan
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Explore the profile of David Millan including associated specialties, affiliations and a list of published articles.
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25
Citations
727
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Recent Articles
1.
Vaswani R, Huang D, Anthony N, Xu L, Centore R, Schiller S, et al.
J Med Chem
. 2025 Jan;
68(2):1772-1792.
PMID: 39801091
BRM (SMARCA2) and BRG1 (SMARCA4) are mutually exclusive ATPase subunits of the mSWI/SNF (BAF) chromatin remodeling complex. BAF is an attractive therapeutic target because of its role in transcription, and...
2.
Sauer C, Hall J, Couturier D, Bradley T, Piskorz A, Griffiths J, et al.
Nat Commun
. 2023 Oct;
14(1):6505.
PMID: 37845213
High-grade serous ovarian carcinoma (HGSOC) is characterised by poor outcome and extreme chromosome instability (CIN). Therapies targeting centrosome amplification (CA), a key mediator of chromosome missegregation, may have significant clinical...
3.
Gershenson D, Miller A, Brady W, Paul J, Carty K, Rodgers W, et al.
Lancet
. 2022 Feb;
399(10324):541-553.
PMID: 35123694
Background: Low-grade serous carcinoma of the ovary or peritoneum is characterised by MAPK pathway aberrations and its reduced sensitivity to chemotherapy relative to high-grade serous carcinoma. We compared the MEK...
4.
Banerjee S, Tang M, OConnell R, Sjoquist K, Clamp A, Millan D, et al.
Gynecol Oncol
. 2021 Aug;
163(1):72-78.
PMID: 34412908
Background: Hormonal therapies are commonly prescribed to patients with metastatic granulosa cell tumours (GCT), based on high response rates in small retrospective studies. Aromatase inhibitors (AIs) are reported to have...
5.
Mileshkin L, Edmondson R, OConnell R, Sjoquist K, Andrews J, Jyothirmayi R, et al.
Gynecol Oncol
. 2019 May;
154(1):29-37.
PMID: 31130288
Background: The clinical benefit rate with aromatase inhibitors and the impact of treatment on quality of life (QOL) in endometrial cancer is unclear. We report the results of a phase...
6.
Bagnoli M, Shi T, Gourley C, Speiser P, Reuss A, Nijman H, et al.
Cells
. 2019 Mar;
8(3).
PMID: 30813545
In the era of personalized medicine, the introduction of translational studies in clinical trials has substantially increased their costs, but provides the possibility of improving the productivity of trials with...
7.
Pan J, Kavanagh K, Cuschieri K, Pollock K, Gilbert D, Millan D, et al.
Int J Cancer
. 2019 Jan;
145(2):427-434.
PMID: 30650180
To assess the excess risk of HPV-associated cancer (HPVaC) in two at-risk groups-women with a previous diagnosis of high grade cervical intraepithelial neoplasia (CIN3) and both men and women treated...
8.
Gonzalez P, OPrey J, Cardaci S, Barthet V, Sakamaki J, Beaumatin F, et al.
Nature
. 2018 Nov;
563(7733):719-723.
PMID: 30464341
It is now well established that tumours undergo changes in cellular metabolism. As this can reveal tumour cell vulnerabilities and because many tumours exhibit enhanced glucose uptake, we have been...
9.
Macintyre G, Goranova T, De Silva D, Ennis D, Piskorz A, Eldridge M, et al.
Nat Genet
. 2018 Aug;
50(9):1262-1270.
PMID: 30104763
The genomic complexity of profound copy number aberrations has prevented effective molecular stratification of ovarian cancers. Here, to decode this complexity, we derived copy number signatures from shallow whole-genome sequencing...
10.
Cooke S, Ennis D, Evers L, Dowson S, Yen Chan M, Paul J, et al.
Clin Cancer Res
. 2017 Sep;
23(24):7633-7640.
PMID: 28954785
We sought to identify the genomic abnormalities in squamous cell carcinomas (SCC) arising in ovarian mature cystic teratoma (MCT), a rare gynecological malignancy of poor prognosis. We performed copy number,...