David M Virshup
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Explore the profile of David M Virshup including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Ricci C, Philpott J, Torgrimson M, Freeberg A, Narasimamurthy R, de Barros E, et al.
bioRxiv
. 2025 Feb;
PMID: 39896482
Circadian rhythms in mammals are tightly regulated through phosphorylation of Period (PER) proteins by Casein Kinase 1 (CK1, subtypes δ and ε). CK1 acts on at least two different regions...
2.
Ang C, Arandjelovic P, Cheng J, Yang J, Guo F, Yu Y, et al.
Cell Rep
. 2024 Dec;
44(1):115093.
PMID: 39721024
Hepatocytes are organized into distinct zonal subsets across the liver lobule, yet their contributions to liver homeostasis and regeneration remain controversial. Here, we developed multiple genetic lineage-tracing mouse models to...
3.
Harold R, Tulsian N, Narasimamurthy R, Yaitanes N, Ayala Hernandez M, Lee H, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(41):e2415567121.
PMID: 39356670
Casein kinase 1δ (CK1δ) controls essential biological processes including circadian rhythms and wingless-related integration site (Wnt) signaling, but how its activity is regulated is not well understood. CK1δ is inhibited...
4.
Harold R, Tulsian N, Narasimamurthy R, Yaitanes N, Ayala Hernandez M, Lee H, et al.
bioRxiv
. 2024 Aug;
PMID: 39131317
Casein kinase controls essential biological processes including circadian rhythms and Wnt signaling, but how its activity is regulated is not well understood. is inhibited by autophosphorylation of its intrinsically disordered...
5.
Yu J, Liao P, Keller T, Cherian J, Virshup D, Xu W
iScience
. 2024 Aug;
27(8):110454.
PMID: 39104418
Wnts are lipid-modified glycoproteins that play key roles in both embryonic development and adult homeostasis. Wnt signaling is dysregulated in many cancers and preclinical data shows that targeting Wnt biosynthesis...
6.
Francisco J, Virshup D
J Biol Chem
. 2024 May;
300(6):107391.
PMID: 38777144
The duration of the transcription-repression cycles that give rise to mammalian circadian rhythms is largely determined by the stability of the PERIOD (PER) protein, the rate-limiting components of the molecular...
7.
Lee Y, Chen L, Chew V, Chow E, Deng L, Hunziker W, et al.
Cancer Res
. 2024 Apr;
84(8):1195-1198.
PMID: 38616656
The 15th annual Frontiers in Cancer Science (FCS) conference gathered scientific experts who shared the latest research converging upon several themes of cancer biology. These themes included the dysregulation of...
8.
Zhong Z, Virshup D
Sci Adv
. 2024 Apr;
10(14):eadk1031.
PMID: 38569029
Pathologic Wnt/β-catenin signaling drives various cancers, leading to multiple approaches to drug this pathway. Appropriate patient selection can maximize success of these interventions. Wnt ligand addiction is a druggable vulnerability...
9.
Madan B, Wadia S, Patnaik S, Harmston N, Tan E, Tan I, et al.
J Clin Invest
. 2024 Mar;
134(6).
PMID: 38488003
Wnts, cholesterol, and MAPK signaling are essential for development and adult homeostasis. Here, we report that fatty acid hydroxylase domain containing 2 (FAXDC2), a previously uncharacterized enzyme, functions as a...
10.
Philpott J, Freeberg A, Park J, Lee K, Ricci C, Hunt S, et al.
Mol Cell
. 2023 May;
83(10):1677-1692.e8.
PMID: 37207626
PERIOD (PER) and Casein Kinase 1δ regulate circadian rhythms through a phosphoswitch that controls PER stability and repressive activity in the molecular clock. CK1δ phosphorylation of the familial advanced sleep...