David M Underhill
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Explore the profile of David M Underhill including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Jena P, Wakita D, Gomez A, Carvalho T, Atici A, Aubuchon E, et al.
Circ Res
. 2025 Mar;
PMID: 40026151
Background: Alterations in the intestinal microbiota contribute to the pathogenesis of various cardiovascular disorders, but how they affect the development of Kawasaki disease, an acute pediatric vasculitis, remains unclear. Here,...
2.
Sanches Santos Rizzo Zuttion M, Parimon T, Bora S, Yao C, Lagree K, Gao C, et al.
J Clin Invest
. 2024 Sep;
134(21).
PMID: 39255040
A leading cause of mortality after influenza infection is the development of a secondary bacterial pneumonia. In the absence of a bacterial superinfection, prescribing antibacterial therapies is not indicated but...
3.
Jaswal K, Todd O, Flores Audelo R, Santus W, Paul S, Singh M, et al.
bioRxiv
. 2024 Aug;
PMID: 39211098
Enteric pathogens engage in complex interactions with the host and the resident microbiota to establish gut colonization. Although mechanistic interactions between enteric pathogens and bacterial commensals have been extensively studied,...
4.
Jena P, Wakita D, Gomez A, Carvalho T, Atici A, Narayanan M, et al.
bioRxiv
. 2024 Jun;
PMID: 38853964
In Brief: It remains unclear whether changes in the intestinal microbiota composition are involved in the development of cardiovascular lesions associated with Kawasaki disease (KD), an immune-mediated vasculitis. Jena observe...
5.
Li K, Chatterjee A, Qian C, Lagree K, Wang Y, Becker C, et al.
Nature
. 2024 Jun;
630(8017):736-743.
PMID: 38839956
Phagocytosis is the process by which myeloid phagocytes bind to and internalize potentially dangerous microorganisms. During phagocytosis, innate immune receptors and associated signalling proteins are localized to the maturing phagosome...
6.
Baik S, Ramanujan V, Becker C, Fett S, Underhill D, Wolf A
Sci Immunol
. 2023 Jun;
8(84):eade7652.
PMID: 37327321
NLRP3 inflammasome activation is a highly regulated process for controlling secretion of the potent inflammatory cytokines IL-1β and IL-18 that are essential during bacterial infection, sterile inflammation, and disease, including...
7.
Santus W, Rana A, Devlin J, Kiernan K, Jacob C, Tjokrosurjo J, et al.
Nat Microbiol
. 2022 Nov;
7(12):2025-2038.
PMID: 36411353
The fungal gut microbiota (mycobiota) has been implicated in diseases that disturb gut homeostasis, such as inflammatory bowel disease. However, little is known about functional relationships between bacteria and fungi...
8.
Tsai C, Caldera J, Hajam I, Chiang A, Tsai C, Li H, et al.
Cell Host Microbe
. 2022 Jul;
30(8):1163-1172.e6.
PMID: 35803276
Humans frequently encounter Staphylococcus aureus (SA) throughout life. Animal studies have yielded SA candidate vaccines, yet all human SA vaccine trials have failed. One notable vaccine "failure" targeted IsdB, critical...
9.
Oh S, Li K, Prince A, Wheeler M, Hamade H, Nguyen C, et al.
Cell Rep
. 2022 Mar;
38(13):110567.
PMID: 35354044
Dectin-1 recognizes β-glucan in fungal cell walls, and activation of Dectin-1 in dendritic cells (DCs) influences immune responses against fungi. Although many studies have shown that DCs activated via Dectin-1...
10.
Underhill D, Braun J
J Clin Invest
. 2022 Mar;
132(5).
PMID: 35229726
The gut microbiome is at the center of inflammatory bowel disease (IBD) pathogenesis and disease activity. While this has mainly been studied in the context of the bacterial microbiome, recent...