Helen S Goodridge
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Explore the profile of Helen S Goodridge including associated specialties, affiliations and a list of published articles.
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69
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3421
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Recent Articles
1.
Wei B, Billman Z, Nozaki K, Goodridge H, Miao E
Front Immunol
. 2024 Jul;
15:1418290.
PMID: 39076995
Inflammasomes are sensors that detect cytosolic microbial molecules or cellular damage, and in response they initiate a form of lytic regulated cell death called pyroptosis. Inflammasomes signal via homotypic protein-protein...
2.
Kang S, Ko E, Andrews A, Shin J, Nance K, Barman P, et al.
J Neuroinflammation
. 2024 Jun;
21(1):150.
PMID: 38840206
Microglia, the brain's resident macrophages, maintain brain homeostasis and respond to injury and infection. During aging they undergo functional changes, but the underlying mechanisms and their contributions to neuroprotection versus...
3.
Aguade-Gorgorio J, Jami-Alahmadi Y, Calvanese V, Kardouh M, Fares I, Johnson H, et al.
Nature
. 2024 Jun;
630(8016):412-420.
PMID: 38839950
The processes that govern human haematopoietic stem cell (HSC) self-renewal and engraftment are poorly understood and challenging to recapitulate in culture to reliably expand functional HSCs. Here we identify MYC...
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Fonseca M, Haro M, Wright K, Lin X, Abbasi F, Sun J, et al.
Nat Genet
. 2023 Jan;
55(2):255-267.
PMID: 36624343
Endometriosis is a common condition in women that causes chronic pain and infertility and is associated with an elevated risk of ovarian cancer. We profiled transcriptomes of >370,000 individual cells...
7.
Piras R, Ko E, Barrett C, De Simone M, Lin X, Broz M, et al.
Nat Commun
. 2022 Nov;
13(1):7243.
PMID: 36433954
Exonic circular RNAs (circRNAs) produce predominantly non-coding RNA species that have been recently profiled in many tumors. However, their functional contribution to cancer progression is still poorly understood. Here, we...
8.
Huang Y, Shin J, Xu A, Yao C, Joung S, Wu M, et al.
iScience
. 2022 Oct;
25(10):105209.
PMID: 36188190
SARS-CoV-2 vaccines have unquestionably blunted the overall impact of the COVID-19 pandemic, but host factors such as age, sex, obesity, and other co-morbidities can affect vaccine efficacy. We identified individuals...
9.
Barman P, Shin J, Lewis S, Kang S, Wu D, Wang Y, et al.
Aging Cell
. 2022 Aug;
21(10):e13701.
PMID: 36040389
Aging is associated with increased monocyte production and altered monocyte function. Classical monocytes are heterogenous and a shift in their subset composition may underlie some of their apparent functional changes...
10.
Hamade H, Stamps J, Stamps D, More S, Thomas L, Blackwood A, et al.
Front Immunol
. 2022 Jul;
13:841065.
PMID: 35812447
The intestinal immune system and microbiota are emerging as important contributors to the development of metabolic syndrome, but the role of intestinal dendritic cells (DCs) in this context is incompletely...