David M Sabatini
Overview
Explore the profile of David M Sabatini including associated specialties, affiliations and a list of published articles.
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Articles
246
Citations
76452
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Recent Articles
11.
Liu G, Jouandin P, Bahng R, Perrimon N, Sabatini D
bioRxiv
. 2023 Jun;
PMID: 37292894
Animals must sense and respond to nutrient availability in their local niche. This task is coordinated in part by the mTOR complex 1 (mTORC1) pathway, which regulates growth and metabolism...
12.
Winter J, Fresenius H, Cunningham C, Wei P, Keys H, Berg J, et al.
Elife
. 2022 Nov;
11.
PMID: 36409067
The tumor suppressor gene is the second most commonly deleted gene in cancer. Such deletions often include portions of the chromosome 10q23 locus beyond the bounds of itself, which frequently...
13.
Laqtom N, Dong W, Medoh U, Cangelosi A, Dharamdasani V, Chan S, et al.
Nature
. 2022 Sep;
609(7929):1005-1011.
PMID: 36131016
Lysosomes have many roles, including degrading macromolecules and signalling to the nucleus. Lysosomal dysfunction occurs in various human conditions, such as common neurodegenerative diseases and monogenic lysosomal storage disorders (LSDs)....
14.
Alvarez S, Sviderskiy V, Terzi E, Papagiannakopoulos T, Moreira A, Adams S, et al.
Nature
. 2022 Sep;
609(7929):E12.
PMID: 36104569
No abstract available.
15.
Gu X, Jouandin P, Lalgudi P, Binari R, Valenstein M, Reid M, et al.
Nature
. 2022 Sep;
609(7929):E11.
PMID: 36100671
No abstract available.
16.
Gu X, Jouandin P, Lalgudi P, Binari R, Valenstein M, Reid M, et al.
Nature
. 2022 Jul;
608(7921):209-216.
PMID: 35859173
Mechanistic target of rapamycin complex 1 (mTORC1) regulates cell growth and metabolism in response to multiple nutrients, including the essential amino acid leucine. Recent work in cultured mammalian cells established...
17.
Valenstein M, Rogala K, Lalgudi P, Brignole E, Gu X, Saxton R, et al.
Nature
. 2022 Jul;
607(7919):610-616.
PMID: 35831510
Mechanistic target of rapamycin complex 1 (mTORC1) controls growth by regulating anabolic and catabolic processes in response to environmental cues, including nutrients. Amino acids signal to mTORC1 through the Rag...
18.
Cangelosi A, Puszynska A, Roberts J, Armani A, Nguyen T, Spinelli J, et al.
Science
. 2022 Jun;
377(6601):47-56.
PMID: 35771919
The mechanistic target of rapamycin complex 1 (mTORC1) kinase controls growth in response to nutrients, including the amino acid leucine. In cultured cells, mTORC1 senses leucine through the leucine-binding Sestrin...
19.
Kanarek N, Keys H, Cantor J, Lewis C, Chan S, Kunchok T, et al.
Nature
. 2022 Jan;
602(7895):E17-E18.
PMID: 35017686
No abstract available.
20.
Spinelli J, Rosen P, Sprenger H, Puszynska A, Mann J, Roessler J, et al.
Science
. 2021 Dec;
374(6572):1227-1237.
PMID: 34855504
For electrons to continuously enter and flow through the mitochondrial electron transport chain (ETC), they must ultimately land on a terminal electron acceptor (TEA), which is known to be oxygen...