David M Frucht
Overview
Explore the profile of David M Frucht including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
34
Citations
2446
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Haverkamp M, Marciano B, Frucht D, Jain A, van de Vosse E, Holland S
J Clin Immunol
. 2014 Apr;
34(4):436-43.
PMID: 24682681
Objective: Patients with hypomorphic mutations in Nuclear Factor-κB Essential Modulator (NEMO) are immunodeficient (ID) and most display ectodermal dysplasia and anhidrosis (EDA). We compared cytokine production by NEMO-ID patients with...
12.
Ouyang W, Torigoe C, Fang H, Xie T, Frucht D
J Biol Chem
. 2013 Dec;
289(7):4180-90.
PMID: 24366872
Hypoxia is considered to be a contributor to the pathology associated with administration of anthrax lethal toxin (LT). However, we report here that serum lactate levels in LT-treated mice are...
13.
Lucas C, Kuehn H, Zhao F, Niemela J, Deenick E, Palendira U, et al.
Nat Immunol
. 2013 Oct;
15(1):88-97.
PMID: 24165795
The p110δ subunit of phosphatidylinositol-3-OH kinase (PI(3)K) is selectively expressed in leukocytes and is critical for lymphocyte biology. Here we report fourteen patients from seven families who were heterozygous for...
14.
Xie T, Sun C, Uslu K, Auth R, Fang H, Ouyang W, et al.
PLoS One
. 2013 Jul;
8(6):e66943.
PMID: 23825096
The scientific community has been restricted by the lack of a practical and informative animal model of gastrointestinal infection with vegetative Bacillus anthracis. We herein report the development of a...
15.
Sun C, Fang H, Xie T, Auth R, Patel N, Murray P, et al.
PLoS One
. 2012 Mar;
7(3):e33583.
PMID: 22438953
A variety of intestinal pathogens have virulence factors that target mitogen activated protein kinase (MAPK) signaling pathways, including Bacillus anthracis. Anthrax lethal toxin (LT) has specific proteolytic activity against the...
16.
Xie T, Auth R, Frucht D
Toxins (Basel)
. 2011 Nov;
3(6):591-607.
PMID: 22069727
The pathological actions of anthrax toxin require the activities of its edema factor (EF) and lethal factor (LF) enzyme components, which gain intracellular access via its receptor-binding component, protective antigen...
17.
Hsu A, Sampaio E, Khan J, Calvo K, Lemieux J, Patel S, et al.
Blood
. 2011 Jun;
118(10):2653-5.
PMID: 21670465
The syndrome of monocytopenia, B-cell and NK-cell lymphopenia, and mycobacterial, fungal, and viral infections is associated with myelodysplasia, cytogenetic abnormalities, pulmonary alveolar proteinosis, and myeloid leukemias. Both autosomal dominant and...
18.
Fang H, Sun C, Xu L, Owen R, Auth R, Snoy P, et al.
J Immunol
. 2010 Oct;
185(9):5463-7.
PMID: 20921524
Neutrophils isolated from BALB/c or C57BL/6 mice and treated in vitro with anthrax lethal toxin release bioactive neutrophil elastase, a proinflammatory mediator of tissue destruction. Similarly, neutrophils isolated from mice...
19.
Vinh D, Patel S, Uzel G, Anderson V, Freeman A, Olivier K, et al.
Blood
. 2009 Dec;
115(8):1519-29.
PMID: 20040766
We identified 18 patients with the distinct clinical phenotype of susceptibility to disseminated nontuberculous mycobacterial infections, viral infections, especially with human papillomaviruses, and fungal infections, primarily histoplasmosis, and molds. This...
20.
Watford W, Hissong B, Durant L, Yamane H, Muul L, Kanno Y, et al.
J Exp Med
. 2008 Nov;
205(12):2803-12.
PMID: 19001140
Tpl2 (Tumor progression locus 2), also known as Cot/MAP3K8, is a hematopoietically expressed serine-threonine kinase. Tpl2 is known to have critical functions in innate immunity in regulating tumor necrosis factor-alpha,...