David M Frucht
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Explore the profile of David M Frucht including associated specialties, affiliations and a list of published articles.
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34
Citations
2446
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Recent Articles
1.
Development of a New Cell-Based AP-1 Gene Reporter Potency Assay for Anti-Anthrax Toxin Therapeutics
Ouyang W, Xie T, Fang H, Frucht D
Toxins (Basel)
. 2023 Sep;
15(9).
PMID: 37755954
Anthrax toxin is a critical virulence factor of . The toxin comprises protective antigen (PA) and two enzymatic moieties, edema factor (EF) and lethal factor (LF), forming bipartite lethal toxin...
2.
Hickerson B, Khalenkov A, Xie T, Frucht D, Scott D, Ilyushina N
Viruses
. 2023 Aug;
15(8).
PMID: 37632039
The recent global COVID-19 pandemic caused by SARS-CoV-2 lasted for over three years. A key measure in combatting this pandemic involved the measurement of the monoclonal antibody (mAb)-mediated inhibition of...
3.
Ouyang W, Xie T, Fang H, Gao C, Stantchev T, Clouse K, et al.
Int J Mol Sci
. 2021 Jul;
22(14).
PMID: 34299155
Proinflammatory cytokine production following infection with severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) is associated with poor clinical outcomes. Like SARS CoV-1, SARS CoV-2 enters host cells via its...
4.
Ouyang W, Frucht D
Int J Mol Sci
. 2021 Apr;
22(8).
PMID: 33918729
Constitutive photomorphogenic 1 (COP1) is the ubiquitin E3 ligase that mediates degradation of c-Jun protein upon Erk1/2 inactivation. It remains unknown how this protein degradation pathway is regulated. In this...
5.
Xie T, Fang H, Ouyang W, Angart P, Chiang M, Bhirde A, et al.
Sci Rep
. 2020 Feb;
10(1):2476.
PMID: 32051479
PEGylated recombinant human granulocyte colony stimulating factor (pegfilgrastim) is used clinically to accelerate immune reconstitution following chemotherapy and is being pursued for biosimilar development. One challenge to overcome in pegfilgrastim...
6.
Ouyang W, Guo P, Takeda K, Fu Q, Fang H, Frucht D
Proc Natl Acad Sci U S A
. 2020 Feb;
117(8):4078-4087.
PMID: 32041890
Anthrax lethal toxin (LT) is a protease virulence factor produced by that is required for its pathogenicity. LT treatment causes a rapid degradation of c-Jun protein that follows inactivation of...
7.
Xie T, Rotstein D, Sun C, Fang H, Frucht D
J Infect Dis
. 2017 Oct;
216(11):1471-1475.
PMID: 28968672
Gastrointestinal (GI) anthrax is the most prevalent form of naturally acquired Bacillus anthracis infection, which is associated with exposure to vegetative bacteria in infected meat (carnivores) or to fermented rumen...
8.
Ouyang W, Guo P, Fang H, Frucht D
J Biol Chem
. 2017 Sep;
292(43):17919-17927.
PMID: 28893904
Anthrax is a life-threatening disease caused by infection with , which expresses lethal factor and the receptor-binding protective antigen. These two proteins combine to form anthrax lethal toxin (LT), whose...
9.
Huang B, Xie T, Rotstein D, Fang H, Frucht D
Toxins (Basel)
. 2015 Oct;
7(10):3960-76.
PMID: 26426050
The principal portal for anthrax infection in natural animal outbreaks is the digestive tract. Enteric exposure to anthrax, which is difficult to detect or prevent in a timely manner, could...
10.
Kuehn H, Ouyang W, Lo B, Deenick E, Niemela J, Avery D, et al.
Science
. 2014 Sep;
345(6204):1623-1627.
PMID: 25213377
Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an inhibitory receptor found on immune cells. The consequences of mutations in CTLA4 in humans are unknown. We identified germline heterozygous mutations in CTLA4...