David M de Kretser
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Explore the profile of David M de Kretser including associated specialties, affiliations and a list of published articles.
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68
Citations
1676
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Recent Articles
1.
Aldahhan R, Stanton P, Ludlow H, de Kretser D, Hedger M
Reprod Sci
. 2021 May;
28(10):2916-2928.
PMID: 34008157
Cryptorchidism causes spermatogenic failure and reduced serum androgen levels, as well as testicular oedema and fibrosis, which are hallmarks of inflammation. However, the role of inflammation and the effects of...
2.
Aldahhan R, Stanton P, Ludlow H, de Kretser D, Hedger M
Mol Cell Endocrinol
. 2019 Aug;
498:110546.
PMID: 31422101
Heat reversibly disrupts spermatogenesis, but the effects on Sertoli cell (SC) function and inhibin/activin-related proteins are less well-defined. Adult rat testis weights decreased by 40% within 2 weeks after heat-treatment...
3.
Marini K, Croucher D, McCloy R, Vaghjiani V, Gonzalez-Rajal A, Hastings J, et al.
Sci Transl Med
. 2018 Jul;
10(451).
PMID: 30045976
Resistance to platinum chemotherapy is a long-standing problem in the management of lung adenocarcinoma. Using a whole-genome synthetic lethal RNA interference screen, we identified activin signaling as a critical mediator...
4.
Richardson A, Lewis D, Kita B, Ludlow H, Groome N, Hedger M, et al.
J Transl Med
. 2018 Apr;
16(1):97.
PMID: 29650052
Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is clinically defined and characterised by persistent disabling tiredness and exertional malaise, leading to functional impairment. Methods: This study introduces the weighted standing time...
5.
Maresch C, Stute D, Alves M, Oliveira P, de Kretser D, Linn T
Hum Reprod Update
. 2017 Nov;
24(1):86-105.
PMID: 29136166
Background: Hyperglycemia can result from a loss of pancreatic beta-cells or a decline in their function leading to decreased insulin secretion or may arise from insulin resistance and variable degrees...
6.
Wijayarathna R, de Kretser D, Meinhardt A, Middendorff R, Ludlow H, Groome N, et al.
Mol Cell Endocrinol
. 2017 Nov;
470:188-198.
PMID: 29111388
Regionalised interaction of the activins, follistatin and inhibin was investigated in the male reproductive tract of mice lacking the inhibin α-subunit (Inha). Serum and intratesticular activin B, although not activin...
7.
Wijayarathna R, de Kretser D, Sreenivasan R, Ludlow H, Middendorff R, Meinhardt A, et al.
Reproduction
. 2017 Oct;
155(1):15-23.
PMID: 29030492
Activin A regulates testicular and epididymal development, but the role of activin B in the epididymis and vas deferens is unknown. Mouse models with reduced activin A ( and ),...
8.
Nicolas N, Muir J, Hayward S, Chen J, Stanton P, Gregorevic P, et al.
Reproduction
. 2017 Jul;
154(3):293-305.
PMID: 28667125
Experimental autoimmune orchitis (EAO) is a rodent model of chronic testicular inflammation that mimics the pathology observed in some types of human infertility. In a previous study, testicular expression of...
9.
Westall G, Snell G, Loskot M, Levvey B, OHehir R, Hedger M, et al.
Transplant Direct
. 2017 Jun;
3(6):e159.
PMID: 28620643
Background: Activins A and B, members of the TGF-β superfamily, are produced as part of the physiological response to tissue damage and the resulting proinflammatory response. Given that lung allograft...
10.
Lidbury B, Kita B, Lewis D, Hayward S, Ludlow H, Hedger M, et al.
J Transl Med
. 2017 Mar;
15(1):60.
PMID: 28302133
Background: Investigations of activin family proteins as serum biomarkers for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). CFS/ME is a disease with complex, wide-ranging symptoms, featuring persistent fatigue of 6 months or...