David M Clarke
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Explore the profile of David M Clarke including associated specialties, affiliations and a list of published articles.
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122
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Recent Articles
1.
Bobevski I, McKenzie D, Rowe H, Kissane D, Clarke D, Fisher J
J Reprod Infant Psychol
. 2018 Sep;
36(5):561-577.
PMID: 30252502
Objective: To examine the psychometric properties of the Demoralisation Scale II (DS-II) and adapt it for use with women in the postnatal period. Background: Demoralisation is a psychological state characterised...
2.
Wright B, Kelsall H, Clarke D, McFarlane A, Sim M
J Health Psychol
. 2018 Mar;
25(10-11):1498-1510.
PMID: 29512405
To understand the role of symptom attribution in treatment-seeking behaviours, survey results of 1356 veterans (age = 38-72 years) were analysed. Controlling for symptom frequency, significant relationships were found for...
3.
Dendle C, Baulch J, Pellicano R, Hay M, Lichtwark I, Ayoub S, et al.
Med Teach
. 2018 Jan;
40(12):1257-1263.
PMID: 29355074
Introduction: The impact of medical student psychological distress on academic performance has not been systematically examined. This study provided an opportunity to closely examine the potential impacts of workplace and...
4.
Loo T, Clarke D
Biochem Pharmacol
. 2017 Aug;
145:27-33.
PMID: 28837794
P-glycoprotein (P-gp) is an ATP-dependent drug pump that protects us from toxic agents and confers multidrug resistance. It has a tweezer-like structure with each arm consisting of a transmembrane domain...
5.
Loo T, Clarke D
Biochem Biophys Res Commun
. 2017 May;
488(4):573-577.
PMID: 28533092
P-glycoprotein (P-gp, ABCB1) is an ABC drug pump that is clinically important because it is involved in multidrug resistance. Many studies have used purified P-gp in detergent (n-dodecyl-β-D-maltoside; DM) micelles...
6.
Loo T, Clarke D
Biochem Pharmacol
. 2017 Apr;
136:24-31.
PMID: 28366727
A large number of correctors have been identified that can partially repair defects in folding, stability and trafficking of CFTR processing mutants that cause cystic fibrosis (CF). The best corrector,...
7.
Loo T, Clarke D
Biochem Biophys Res Commun
. 2016 Dec;
483(1):366-370.
PMID: 28025146
P-glycoprotein (P-gp) is an ABC (ATP-Binding Cassette) drug pump that is clinically important because it confers multidrug resistance. Drugs bind at the interface between the transmembrane domains to activate ATPase...
8.
Robinson S, Kissane D, Brooker J, Michael N, Fischer J, Franco M, et al.
Cancer
. 2016 May;
122(14):2251-9.
PMID: 27171617
Background: The Demoralization Scale (DS) was initially validated in 2004 to enable the measurement of demoralization in patients with advanced cancer. Subsequent shortcomings indicated the need for psychometric strengthening. Here,...
9.
Robinson S, Kissane D, Brooker J, Hempton C, Michael N, Fischer J, et al.
Cancer
. 2016 May;
122(14):2260-7.
PMID: 27171544
Background: The recently refined Demoralization Scale-II (DS-II) is a 16-item, self-report measure of demoralization. Its 2 factors-Meaning and Purpose and Distress and Coping Ability-demonstrate sound internal validity, including item fit,...
10.
Loo T, Clarke D
Biochemistry
. 2016 May;
55(20):2817-20.
PMID: 27159830
Drug substrates stimulate ATPase activity of the P-glycoprotein (P-gp) ATP-binding cassette drug pump by an unknown mechanism. Cross-linking analysis was performed to test if drug substrates stimulate P-gp ATPase activity...