David Lagares
Overview
Explore the profile of David Lagares including associated specialties, affiliations and a list of published articles.
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46
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2253
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Recent Articles
1.
Flaxman H, Chrysovergi M, Han H, Kabir F, Lister R, Chang C, et al.
JCI Insight
. 2024 Jun;
9(15).
PMID: 38900587
Pathological deposition and crosslinking of collagen type I by activated myofibroblasts drives progressive tissue fibrosis. Therapies that inhibit collagen synthesis have potential as antifibrotic agents. We identify the collagen chaperone...
2.
Novaes G, Lima C, Longo C, Machado P, Silva T, Olberg G, et al.
Mol Ther
. 2024 Jan;
32(2):440-456.
PMID: 38213031
Here we introduce a first-in-class microRNA-sensitive oncolytic Zika virus (ZIKV) for virotherapy application against central nervous system (CNS) tumors. The described methodology produced two synthetic modified ZIKV strains that are...
3.
Vukmirovic M, Benam K, Rose J, Turner S, Magin C, Lagares D, et al.
Ann Am Thorac Soc
. 2023 Oct;
21(1):1-11.
PMID: 37903340
"Translational medicine" has been a buzzword for over two decades. The concept was intended to be lofty, to reflect a new "bench-to-bedside" approach to basic and clinical research that would...
4.
Yamamura Y, Sakai N, Iwata Y, Lagares D, Hara A, Kitajima S, et al.
FASEB J
. 2023 Jun;
37(7):e23005.
PMID: 37289107
Fibroblast accumulation and extracellular matrix (ECM) deposition are common critical steps for the progression of organ fibrosis, but the precise molecular mechanisms remain to be fully investigated. We have previously...
5.
6.
Flaxman H, Chrysovergi M, Han H, Kabir F, Lister R, Chang C, et al.
bioRxiv
. 2023 Mar;
PMID: 36945535
Pathological deposition and crosslinking of collagen type I by activated myofibroblasts drives progressive tissue fibrosis. Therapies that inhibit collagen synthesis by myofibroblasts have clinical potential as anti-fibrotic agents. Lysine hydroxylation...
7.
Jeong M, Han H, Lagares D, Im H
ACS Pharmacol Transl Sci
. 2022 Aug;
5(8):520-538.
PMID: 35983278
Pulmonary fibrosis is a serious, progressive lung disease characterized by scarring and stiffening lung tissues, affecting the respiratory system and leading to organ failure. It is a complex disease consisting...
8.
Dieffenbach P, Mallarino Haeger C, Rehman R, Corcoran A, Coronata A, Vellarikkal S, et al.
Am J Respir Crit Care Med
. 2021 Sep;
204(12):1433-1451.
PMID: 34550870
Mechanical signaling through cell-matrix interactions plays a major role in progressive vascular remodeling in pulmonary arterial hypertension (PAH). MMP-8 (matrix metalloproteinase-8) is an interstitial collagenase involved in regulating inflammation and...
9.
Merkt W, Zhou Y, Han H, Lagares D
Wound Repair Regen
. 2021 Jun;
29(4):678-691.
PMID: 34117675
In response to tissue injury, fibroblasts differentiate into professional repair cells called myofibroblasts, which orchestrate many aspects of the normal tissue repair programme including synthesis, deposition and contraction of extracellular...
10.
Lagares D, Hinz B
Methods Mol Biol
. 2021 May;
2299:277-290.
PMID: 34028750
Reductionist cell culture systems are not only convenient but essential to understand molecular mechanisms of myofibroblast activation and action in carefully controlled conditions. However, tissue myofibroblasts do not act in...