David L Krull
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Explore the profile of David L Krull including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
125
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0
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Recent Articles
1.
Bonnevie E, Dobrzynski E, Steiner D, Hildebrand D, Monslow J, Singh M, et al.
Sci Rep
. 2023 Dec;
13(1):21759.
PMID: 38066073
Over the past decade, automation of digital image analysis has become commonplace in both research and clinical settings. Spurred by recent advances in artificial intelligence and machine learning (AI/ML), tissue...
2.
Brown H, Castellino S, Groseclose M, Elangbam C, Mellon-Kusibab K, Yoon L, et al.
Toxicol Pathol
. 2016 Jan;
44(1):112-31.
PMID: 26733602
Nevirapine (NVP) is associated with hepatotoxicity in 1-5% of patients. In rodent studies, NVP has been shown to cause hepatic enzyme induction, centrilobular hypertrophy, and skin rash in various rat...
3.
Krull D, Peterson R
Methods Cell Biol
. 2011 Jun;
102:291-308.
PMID: 21704843
Preclinical drug development is actively involved in testing compounds to find cures or to manage the effects of disease, such as diabetes. Animal models, such as the Zucker diabetic fatty...
4.
Peterson R, Krull D, Brown H, de Serres M
Drug Metab Lett
. 2010 Jul;
4(3):180-4.
PMID: 20642451
Morphological evaluation of humanized chimeric mouse livers from the PhoenixBio (uPA(+/+)/SCID) mouse model show robust replacement and expansion with human hepatocytes, however areas of human hepatocytes had prominent steatosis and...
5.
Peterson R, Krull D, Butler L
Toxicol Pathol
. 2008 Mar;
36(1):117-32.
PMID: 18337230
Laser scanning cytometry (LSC) is a powerful tool for qualitative and quantitative analysis of tissue sections in preclinical drug development. LSC combines the strengths of flow cytometry with tissue architecture...
6.
Masson M, Peterson R, Chung C, Graf M, Carpenter L, Ambroso J, et al.
Chem Res Toxicol
. 2007 Jan;
20(1):20-6.
PMID: 17226923
Current evidence suggests that drug-induced liver disease can be caused by an allergic response (drug-induced allergic hepatitis, DIAH) induced by hepatic drug-protein adducts. The relatively low incidence of these reactions...
7.
Elangbam C, Wehe J, Barton J, Krull D, Nyska A, Crabbs T, et al.
Exp Toxicol Pathol
. 2006 Sep;
58(2-3):89-99.
PMID: 16996724
Spontaneous valvulopathy has been described as nodular or segmental thickenings composed of fibromyxoid tissue in the subendocardium of various valve-leaflets in aging rats, but its pathogenesis and significance are incompletely...
8.
Seeger T, Bartlett B, Coskran T, Culp J, James L, Krull D, et al.
Brain Res
. 2003 Sep;
985(2):113-26.
PMID: 12967715
PDE10A is a newly identified cAMP/cGMP phosphodiesterase for which mRNA is highly expressed in the mammalian striatum. In the present study, PDE10A protein and mRNA expression throughout the rat brain...