Chandikumar S Elangbam
Overview
Explore the profile of Chandikumar S Elangbam including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
142
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Recent Articles
1.
Brown H, Castellino S, Groseclose M, Elangbam C, Mellon-Kusibab K, Yoon L, et al.
Toxicol Pathol
. 2016 Jan;
44(1):112-31.
PMID: 26733602
Nevirapine (NVP) is associated with hepatotoxicity in 1-5% of patients. In rodent studies, NVP has been shown to cause hepatic enzyme induction, centrilobular hypertrophy, and skin rash in various rat...
2.
Faber C, Zhu Z, Castellino S, Wagner D, Brown R, Peterson R, et al.
J Appl Toxicol
. 2014 Aug;
34(11):1122-9.
PMID: 25132005
Cardiolipin (CL) is crucial for mitochondrial energy metabolism and structural integrity. Alterations in CL quantity or CL species have been associated with mitochondrial dysfunction in several pathological conditions and diseases,...
3.
Myer J, Romach E, Elangbam C
Toxicol Pathol
. 2013 Nov;
42(1):260-74.
PMID: 24178573
Compound-induced pancreatic injury is a serious liability in preclinical toxicity studies. However, its relevance to humans should be cautiously evaluated because of interspecies variations. To highlight such variations, we evaluated...
4.
Morgan S, Elangbam C, Berens S, Janovitz E, Vitsky A, Zabka T, et al.
Toxicol Pathol
. 2012 Sep;
41(3):508-18.
PMID: 22968286
Animal models of human disease are commonly utilized to gain insight into the potential efficacy and mode of action of novel pharmaceuticals. However, conventional (healthy) rodent and nonrodent models are...
5.
Slocum N, Durrant J, Bailey D, Yoon L, Jordan H, Barton J, et al.
Exp Toxicol Pathol
. 2012 May;
65(5):549-57.
PMID: 22542811
Drug-induced weight loss in humans has been associated with undesirable side effects not present in weight loss from lifestyle interventions (caloric restriction or exercise). To investigate the mechanistic differences of...
6.
Elangbam C
Toxicol Pathol
. 2010 Aug;
38(6):837-48.
PMID: 20716786
Drug-induced valvulopathy is a serious liability for certain compound classes in development and for some marketed drugs intended for human use. Reports of valvulopathy led to the withdrawal of fenfluramines...
7.
Elangbam C, Job L, Zadrozny L, Barton J, Yoon L, Gates L, et al.
Exp Toxicol Pathol
. 2008 May;
60(4-5):253-62.
PMID: 18511249
Several drugs have been linked to valvulopathy in humans, including therapeutic agents for obesity, Parkinson's disease and migraine. There is increasing evidence that the 5-hydroxytryptamine 2B receptor (5HT2BR) activation and/or...
8.
Elangbam C, Wehe J, Barton J, Krull D, Nyska A, Crabbs T, et al.
Exp Toxicol Pathol
. 2006 Sep;
58(2-3):89-99.
PMID: 16996724
Spontaneous valvulopathy has been described as nodular or segmental thickenings composed of fibromyxoid tissue in the subendocardium of various valve-leaflets in aging rats, but its pathogenesis and significance are incompletely...
9.
Elangbam C, Lightfoot R, Yoon L, Creech D, Geske R, Crumbley C, et al.
J Histochem Cytochem
. 2005 May;
53(5):671-7.
PMID: 15872060
5-Hydroxytryptamine-2B receptor (5HT2BR) stimulation is known to cause fibroblast mitogenesis, and the mitogenic effect has been proposed to trigger valvular heart disease in humans. In this study, we used real-time...
10.
Elangbam C, Colman K, Lightfoot R, Tyler R, Wall H
Toxicol Pathol
. 2002 Aug;
30(4):483-91.
PMID: 12187939
A full assessment of all heart valves in rats and mice is often impractical and is usually not performed in routine toxicity studies, largely due to an inevitable inconsistency of...