David L Hava
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Explore the profile of David L Hava including associated specialties, affiliations and a list of published articles.
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25
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Recent Articles
1.
Lubkowicz D, Hava D, Lewis K, Isabella V
ACS Synth Biol
. 2024 Apr;
13(4):1077-1084.
PMID: 38588591
Uremic toxins (UTs) are microbiota-derived metabolites that accelerate the progression of kidney damage in patients with chronic kidney disease (CKD). One of the major UTs involved in CKD progression is...
2.
Perreault M, Means J, Gerson E, James M, Cotton S, Bergeron C, et al.
Cell Host Microbe
. 2024 Feb;
32(3):382-395.e10.
PMID: 38309259
Methionine is an essential proteinogenic amino acid, but its excess can lead to deleterious effects. Inborn errors of methionine metabolism resulting from loss of function in cystathionine β-synthase (CBS) cause...
3.
Luke J, Piha-Paul S, Medina T, Verschraegen C, Varterasian M, Brennan A, et al.
Clin Cancer Res
. 2023 May;
29(13):2435-2444.
PMID: 37227176
Purpose: SYNB1891 is a live, modified strain of the probiotic Escherichia coli Nissle 1917 (EcN) engineered to produce cyclic dinucleotides under hypoxia, leading to STimulator of INterferon Genes (STING) activation...
4.
Kouno T, Zeng S, Wang Y, Duan Y, Lang S, Gao B, et al.
Alcohol Clin Exp Res (Hoboken)
. 2023 Mar;
47(5):856-867.
PMID: 36871955
Background And Purpose: Gut bacteria metabolize tryptophan into indoles. Intestinal levels of the tryptophan metabolite indole-3-acetic acid are reduced in patients with alcohol-associated hepatitis. Supplementation of indole-3-acetic acid protects against...
5.
Kalantari A, James M, Renaud L, Perreault M, Monahan C, McDonald M, et al.
PLoS One
. 2023 Feb;
18(2):e0280499.
PMID: 36730255
E. coli Nissle (EcN) is a non-pathogenic probiotic bacterium of the Enterobacteriaceae family that has been used for over a century to promote general gut health. Despite the history of...
6.
Lubkowicz D, Horvath N, James M, Cantarella P, Renaud L, Bergeron C, et al.
Mol Syst Biol
. 2022 Mar;
18(3):e10539.
PMID: 35253995
Enteric hyperoxaluria (EH) is a metabolic disease caused by excessive absorption of dietary oxalate leading to the formation of chronic kidney stones and kidney failure. There are no approved pharmaceutical...
7.
Cable J, Leonard J, Lu T, Xie Z, Chang M, Fernandez L, et al.
Ann N Y Acad Sci
. 2021 Nov;
1506(1):98-117.
PMID: 34786712
Synthetic biology has the potential to transform cell- and gene-based therapies for a variety of diseases. Sophisticated tools are now available for both eukaryotic and prokaryotic cells to engineer cells...
8.
Curran A, Hava D
Antibiotics (Basel)
. 2021 Apr;
10(4).
PMID: 33800658
spp. are spore forming molds; a subset of which are clinically relevant to humans and can cause significant morbidity and mortality. causes chronic infection in patients with chronic lung disease...
9.
Hava D, Tan L, Johnson P, Curran A, Perry J, Kramer S, et al.
Br J Clin Pharmacol
. 2019 Nov;
86(4):723-733.
PMID: 31696544
Aims: Oral itraconazole has variable pharmacokinetics and risks of adverse events associated with high plasma exposure. An inhalation formulation of itraconazole (PUR1900) is being developed to treat allergic bronchopulmonary aspergillosis,...
10.
Kuehl P, Chand R, McDonald J, Hava D, DeHaan W
AAPS PharmSciTech
. 2019 Jul;
20(6):242.
PMID: 31264190
The utilization of ferrets as a non-clinical model for disease is rapidly increasing within drug development. Many of these models include respiratory diseases that involve targeted drug delivery via nose-only...