David Knoff
Overview
Explore the profile of David Knoff including associated specialties, affiliations and a list of published articles.
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5
Citations
289
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0
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Recent Articles
1.
Tanguturi S, Trippa L, Ramkissoon S, Pelton K, Knoff D, Sandak D, et al.
Neuro Oncol
. 2017 Mar;
19(7):908-917.
PMID: 28339723
Background: Biomarkers can improve clinical trial efficiency, but designing and interpreting biomarker-driven trials require knowledge of relationships among biomarkers, clinical covariates, and endpoints. We investigated these relationships across genomic subgroups...
2.
Bandopadhayay P, Ramkissoon L, Jain P, Bergthold G, Wala J, Zeid R, et al.
Nat Genet
. 2016 Feb;
48(3):273-82.
PMID: 26829751
Angiocentric gliomas are pediatric low-grade gliomas (PLGGs) without known recurrent genetic drivers. We performed genomic analysis of new and published data from 249 PLGGs, including 19 angiocentric gliomas. We identified...
3.
Preclinical Efficacy of the MDM2 Inhibitor RG7112 in MDM2-Amplified and TP53 Wild-type Glioblastomas
Verreault M, Schmitt C, Goldwirt L, Pelton K, Haidar S, Levasseur C, et al.
Clin Cancer Res
. 2015 Oct;
22(5):1185-96.
PMID: 26482041
Purpose: p53 pathway alterations are key molecular events in glioblastoma (GBM). MDM2 inhibitors increase expression and stability of p53 and are presumed to be most efficacious in patients with TP53...
4.
Ramkissoon S, Bi W, Schumacher S, Ramkissoon L, Haidar S, Knoff D, et al.
Neuro Oncol
. 2015 Mar;
17(10):1344-55.
PMID: 25754088
Background: Multidimensional genotyping of formalin-fixed paraffin-embedded (FFPE) samples has the potential to improve diagnostics and clinical trials for brain tumors, but prospective use in the clinical setting is not yet...
5.
Kalinowski A, Ueki I, Min-Oo G, Ballon-Landa E, Knoff D, Galen B, et al.
Am J Physiol Lung Cell Mol Physiol
. 2014 May;
307(2):L186-96.
PMID: 24838750
Airway epithelial cells are the primary cell type involved in respiratory viral infection. Upon infection, airway epithelium plays a critical role in host defense against viral infection by contributing to...