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Steven E Schumacher

Explore the profile of Steven E Schumacher including associated specialties, affiliations and a list of published articles. Areas
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Articles 44
Citations 10454
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Recent Articles
1.
Rodriguez-Martin B, Alvarez E, Baez-Ortega A, Zamora J, Supek F, Demeulemeester J, et al.
Nat Genet . 2023 Mar; 55(6):1080. PMID: 36944736
No abstract available.
2.
Li Y, Roberts N, Wala J, Shapira O, Schumacher S, Kumar K, et al.
Nature . 2023 Jan; 614(7948):E38. PMID: 36697835
No abstract available.
3.
Rheinbay E, Nielsen M, Abascal F, Wala J, Shapira O, Tiao G, et al.
Nature . 2023 Jan; 614(7948):E40. PMID: 36697832
No abstract available.
4.
Gao G, Oh C, Saksena G, Deng D, Westlake L, Hill B, et al.
Bioinformatics . 2022 Aug; 38(20):4677-4686. PMID: 36040167
Motivation: Somatic copy-number alterations (SCNAs) play an important role in cancer development. Systematic noise in sequencing and array data present a significant challenge to the inference of SCNAs for cancer...
5.
Dentro S, Leshchiner I, Haase K, Tarabichi M, Wintersinger J, Deshwar A, et al.
Cell . 2021 Apr; 184(8):2239-2254.e39. PMID: 33831375
Intra-tumor heterogeneity (ITH) is a mechanism of therapeutic resistance and therefore an important clinical challenge. However, the extent, origin, and drivers of ITH across cancer types are poorly understood. To...
6.
Rheinbay E, Nielsen M, Abascal F, Wala J, Shapira O, Tiao G, et al.
Nature . 2020 Feb; 578(7793):102-111. PMID: 32025015
The discovery of drivers of cancer has traditionally focused on protein-coding genes. Here we present analyses of driver point mutations and structural variants in non-coding regions across 2,658 genomes from...
7.
Li Y, Roberts N, Wala J, Shapira O, Schumacher S, Kumar K, et al.
Nature . 2020 Feb; 578(7793):112-121. PMID: 32025012
A key mutational process in cancer is structural variation, in which rearrangements delete, amplify or reorder genomic segments that range in size from kilobases to whole chromosomes. Here we develop...
8.
Rodriguez-Martin B, Alvarez E, Baez-Ortega A, Zamora J, Supek F, Demeulemeester J, et al.
Nat Genet . 2020 Feb; 52(3):306-319. PMID: 32024998
About half of all cancers have somatic integrations of retrotransposons. Here, to characterize their role in oncogenesis, we analyzed the patterns and mechanisms of somatic retrotransposition in 2,954 cancer genomes...
9.
Wong G, Zhou J, Liu J, Wu Z, Xu X, Li T, et al.
Nat Med . 2018 Aug; 24(10):1627. PMID: 30093730
In the Supplementary Information originally published with this article, a lane was missing in the β-actin blot in Supplementary Fig. 2. The lane has been added. The error has been...
10.
Wong G, Zhou J, Liu J, Wu Z, Xu X, Li T, et al.
Nat Med . 2018 May; 24(7):968-977. PMID: 29808010
The role of KRAS, when activated through canonical mutations, has been well established in cancer. Here we explore a secondary means of KRAS activation in cancer: focal high-level amplification of...