David K Welsh
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Explore the profile of David K Welsh including associated specialties, affiliations and a list of published articles.
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63
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3967
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Recent Articles
1.
Whittaker D, Akhmetova L, Carlin D, Romero H, Welsh D, Colwell C, et al.
Cell Metab
. 2023 Aug;
35(10):1704-1721.e6.
PMID: 37607543
Circadian disruptions impact nearly all people with Alzheimer's disease (AD), emphasizing both their potential role in pathology and the critical need to investigate the therapeutic potential of circadian-modulating interventions. Here,...
2.
Porcu A, Nilsson A, Booreddy S, Barnes S, Welsh D, Dulcis D
Sci Adv
. 2022 Sep;
8(35):eabn9867.
PMID: 36054362
Seasonal changes in day length (photoperiod) affect numerous physiological functions. The suprachiasmatic nucleus (SCN)-paraventricular nucleus (PVN) axis plays a key role in processing photoperiod-related information. Seasonal variations in SCN and...
3.
Meadows J, Breuer J, Lavalle S, Hirschenberger M, Patel M, Nguyen D, et al.
Mol Metab
. 2022 Jan;
57:101431.
PMID: 34974160
Objective: The increasing prevalence of obesity makes it important to increase the understanding of the maturation and function of the neuronal integrators and regulators of metabolic function. Methods: Behavioral, molecular,...
4.
Hoffmann H, Meadows J, Breuer J, Yaw A, Nguyen D, Tonsfeldt K, et al.
J Neurosci Res
. 2021 Jul;
99(10):2625-2645.
PMID: 34212416
The homeodomain transcription factors sine oculis homeobox 3 (Six3) and ventral anterior homeobox 1 (Vax1) are required for brain development. Their expression in specific brain areas is maintained in adulthood,...
5.
Mishra H, Ying N, Luis A, Wei H, Nguyen M, Nakhla T, et al.
Mol Psychiatry
. 2021 Mar;
26(7):3383-3394.
PMID: 33674753
Bipolar disorder (BD) is a neuropsychiatric illness defined by recurrent episodes of mania/hypomania, depression and circadian rhythm abnormalities. Lithium is an effective drug for BD, but 30-40% of patients fail...
6.
Evans J, Welsh D, Davidson A
Methods Mol Biol
. 2020 Dec;
2130:287-294.
PMID: 33284452
Circadian rhythms in cellular function can be monitored in real time with bioluminescence imaging. In this approach, bioluminescence is produced by an enzymatic reaction, which can be used to report...
7.
Porcu A, Vaughan M, Nilsson A, Arimoto N, Lamia K, Welsh D
Proc Natl Acad Sci U S A
. 2020 Jun;
117(24):13771-13782.
PMID: 32487727
The nucleus accumbens (NAc), a central component of the midbrain dopamine reward circuit, exhibits disturbed circadian rhythms in the postmortem brains of depressed patients. We hypothesized that normal mood regulation...
8.
Haque S, Booreddy S, Welsh D
Yale J Biol Med
. 2019 Jun;
92(2):251-258.
PMID: 31249486
is the only single circadian clock gene that is essential for rhythmic gene expression in the mammalian circadian timing system. Genetic approaches targeting expression have been used to further assess...
9.
McCarthy M, Wei H, Nievergelt C, Stautland A, Maihofer A, Welsh D, et al.
Neuropsychopharmacology
. 2018 Nov;
44(3):620-628.
PMID: 30487653
Bipolar disorder (BD) is a serious mood disorder associated with circadian rhythm abnormalities. Risk for BD is genetically encoded and overlaps with systems that maintain circadian rhythms. Lithium is an...
10.
Huhne A, Welsh D, Landgraf D
Ann Med
. 2018 Sep;
50(8):637-654.
PMID: 30265156
Disruption of circadian clocks is strongly associated with mood disorders. Chronotherapies targeting circadian rhythms have been shown to be very effective treatments of mood disorders, but still are not widely...