David Jimenez-Morales
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Explore the profile of David Jimenez-Morales including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
631
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Recent Articles
11.
Lee S, Liu X, Jimenez-Morales D, Rinaudo P
Elife
. 2022 Sep;
11.
PMID: 36107481
In vitro fertilization (IVF) has resulted in the birth of over 8 million children. Although most IVF-conceived children are healthy, several studies suggest an increased risk of altered growth rate,...
12.
Parikh V, Ioannidis A, Jimenez-Morales D, Gorzynski J, De Jong H, Liu X, et al.
Nat Commun
. 2022 Aug;
13(1):5107.
PMID: 36042219
The SARS-CoV-2 pandemic has differentially impacted populations across race and ethnicity. A multi-omic approach represents a powerful tool to examine risk across multi-ancestry genomes. We leverage a pandemic tracking strategy...
13.
Mitchell G, Silvis M, Talkington K, Budzik J, Dodd C, Paluba J, et al.
mBio
. 2022 Jan;
13(1):e0272621.
PMID: 35073755
Ceragenins are a family of synthetic amphipathic molecules designed to mimic the properties of naturally occurring cationic antimicrobial peptides (CAMPs). Although ceragenins have potent antimicrobial activity, whether their mode of...
14.
Lindholm M, Jimenez-Morales D, Zhu H, Seo K, Amar D, Zhao C, et al.
Circ Genom Precis Med
. 2021 Nov;
14(6):e003419.
PMID: 34802252
Background: ACTN2 (alpha-actinin 2) anchors actin within cardiac sarcomeres. The mechanisms linking mutations to myocardial disease phenotypes are unknown. Here, we characterize patients with novel mutations to reveal insights into...
15.
Swaney D, Ramms D, Wang Z, Park J, Goto Y, Soucheray M, et al.
Science
. 2021 Sep;
374(6563):eabf2911.
PMID: 34591642
We outline a framework for elucidating tumor genetic complexity through multidimensional protein-protein interaction maps and apply it to enhancing our understanding of head and neck squamous cell carcinoma. This network...
16.
Martin-Sancho L, Tripathi S, Rodriguez-Frandsen A, Pache L, Sanchez-Aparicio M, McGregor M, et al.
Nat Microbiol
. 2021 Sep;
6(10):1319-1333.
PMID: 34556855
The fate of influenza A virus (IAV) infection in the host cell depends on the balance between cellular defence mechanisms and viral evasion strategies. To illuminate the landscape of IAV...
17.
Paulo E, Zhang Y, Masand R, Huynh T, Seo Y, Swaney D, et al.
Cell Rep
. 2021 Sep;
36(12):109742.
PMID: 34551310
Cold-induced thermogenesis in endotherms demands adaptive thermogenesis fueled by mitochondrial respiration and Ucp1-mediated uncoupling in multilocular brown adipocytes (BAs). However, dietary regulation of thermogenesis in BAs isn't fully understood. Here,...
18.
Tsvetanova N, Trester-Zedlitz M, Newton B, Peng G, Johnson J, Jimenez-Morales D, et al.
J Biol Chem
. 2021 Jun;
297(1):100907.
PMID: 34166681
Endosomal signaling downstream of G-protein-coupled receptors (GPCRs) has emerged as a novel paradigm with important pharmacological and physiological implications. However, our knowledge of the functional consequences of intracellular signaling is...
19.
Wilk A, Lee M, Wei B, Parks B, Pi R, Martinez-Colon G, et al.
J Exp Med
. 2021 Jun;
218(8).
PMID: 34128959
Our understanding of protective versus pathological immune responses to SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of patients at the extremes of the...
20.
Gorzynski J, De Jong H, Amar D, Hughes C, Ioannidis A, Bierman R, et al.
medRxiv
. 2020 Aug;
PMID: 32766602
During COVID19 and other viral pandemics, rapid generation of host and pathogen genomic data is critical to tracking infection and informing therapies. There is an urgent need for efficient approaches...