David J Richard
Overview
Explore the profile of David J Richard including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
146
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Recent Articles
11.
Verheijen J, Richard D, Curran K, Kaplan J, Lefever M, Nowak P, et al.
J Med Chem
. 2009 Nov;
52(24):8010-24.
PMID: 19894727
Design and synthesis of a series of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as potent and selective inhibitors of the mammalian target of rapamycin (mTOR) are described. Optimization of the 6-aryl substituent led to the...
12.
Zask A, Verheijen J, Curran K, Kaplan J, Richard D, Nowak P, et al.
J Med Chem
. 2009 Aug;
52(16):5013-6.
PMID: 19645448
The mammalian target of rapamycin (mTOR), a central regulator of growth, survival, and metabolism, is a validated target for cancer therapy. Rapamycin and its analogues, allosteric inhibitors of mTOR, only...
13.
Joullie M, Richard D
Chem Commun (Camb)
. 2004 Sep;
(18):2011-5.
PMID: 15367952
Recent progress in the synthesis and investigation of the biological activities of cyclopeptide alkaloids is reviewed. New strategies have been devised to overcome some of the synthetic challenges inherent in...
14.
Richard D, Schiavi B, Joullie M
Proc Natl Acad Sci U S A
. 2004 May;
101(33):11971-6.
PMID: 15141083
The syntheses of isoroquefortine C and a related heterocycle were achieved by implementation of both intra- and intermolecular vinyl amidation reactions. These accomplishments represent a significant advance in the use...
15.
Schiavi B, Richard D, Joullie M
J Org Chem
. 2002 Feb;
67(3):620-4.
PMID: 11855998
A short and efficient total synthesis of isoroquefortine C, the 3,12-(Z)-isomer of roquefortine C, from L-tryptophan methyl ester hydrochloride and 4(5)-(hydroxy)methylimidazole hydrochloride is described.