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David J Pinsky

Explore the profile of David J Pinsky including associated specialties, affiliations and a list of published articles. Areas
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Articles 97
Citations 2811
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Recent Articles
11.
Ashur C, Norton E, Farhat L, Conlon A, Willer C, Froehlich J, et al.
Sci Rep . 2020 Mar; 10(1):4723. PMID: 32170215
Triggering events for acute aortic dissections are incompletely understood. We sought to investigate whether there is an association between admission for acute type A aortic dissection (ATAAD) to the University...
12.
Sutton N, Bouis D, Mann K, Rashid I, McCubbrey A, Hyman M, et al.
Arterioscler Thromb Vasc Biol . 2019 Oct; 40(1):61-71. PMID: 31619062
Objective: CD73 is an ectonucleotidase which catalyzes the conversion of AMP (adenosine monophosphate) to adenosine. Adenosine has been shown to be anti-inflammatory and vasorelaxant. The impact of ectonucleotidases on age-dependent...
13.
Ali R, Gandhi A, Meng H, Yalavarthi S, Vreede A, Estes S, et al.
Nat Commun . 2019 Apr; 10(1):1916. PMID: 31015489
Potentiation of neutrophil extracellular trap (NET) release is one mechanism by which antiphospholipid antibodies (aPL Abs) effect thrombotic events in patients with antiphospholipid syndrome (APS). Surface adenosine receptors trigger cyclic...
14.
Yadav V, Chi L, Zhao R, Tourdot B, Yalavarthi S, Jacobs B, et al.
J Clin Invest . 2019 Apr; 129(7):2872-2877. PMID: 30990798
Deep vein thrombosis (DVT), caused by alterations in venous homeostasis is the third most common cause of cardiovascular mortality; however, key molecular determinants in venous thrombosis have not been fully...
15.
Anyanwu A, Kanthi Y, Fukase K, Liao H, Mimura T, Desch K, et al.
Arterioscler Thromb Vasc Biol . 2019 Mar; 39(4):e118-e129. PMID: 30816804
Objective- Leukocyte flux contributes to thrombus formation in deep veins under pathological conditions, but mechanisms that inhibit venous thrombosis are incompletely understood. Ectonucleotide di(tri)phosphohydrolase 1 ( ENTPD1 or Cd39), an...
16.
Pinsky D
Trans Am Clin Climatol Assoc . 2018 Sep; 129:132-139. PMID: 30166707
A common thread underlying vascular or tissue injury is the loss of plasmalemmal integrity and the passive (or even active) spillage of intracellular contents into the circulation. Purinergic nucleotides, which...
17.
Knight J, Mazza L, Yalavarthi S, Sule G, Ali R, Hodgin J, et al.
Front Immunol . 2018 Jun; 9:1322. PMID: 29942314
Objectives: CD39 and CD73 are surface enzymes that jut into the extracellular space where they mediate the step-wise phosphohydrolysis of the autocrine and paracrine danger signals ATP and ADP into...
18.
Rattan R, Bhattacharjee S, Zong H, Swain C, Siddiqui M, Visovatti S, et al.
Bioorg Med Chem . 2017 Jul; 25(16):4487-4496. PMID: 28705434
The surface properties of nanoparticles (NPs) are a major factor that influences how these nanomaterials interact with biological systems. Interactions between NPs and macrophages of the reticuloendothelial system (RES) can...
19.
Baek A, Sutton N, Petrovic-Djergovic D, Liao H, Ray J, Park J, et al.
Circulation . 2017 Apr; 135(24):2389-2402. PMID: 28377485
Background: Cerebral tissue damage after an ischemic event can be exacerbated by inflammation and thrombosis. Elevated extracellular ATP and ADP levels are associated with cellular injury, inflammation, and thrombosis. Ectonucleoside...
20.
Sutton N, Hayasaki T, Hyman M, Anyanwu A, Liao H, Petrovic-Djergovic D, et al.
JCI Insight . 2017 Jan; 2(1):e89504. PMID: 28097233
Mechanical complications of myocardial infarction (MI) are often fatal. Little is known about endogenous factors that predispose to myocardial rupture after MI. Ectonucleoside triphosphate diphosphohydrolase (CD39) could be a critical...