David J Morgans Jr
Overview
Explore the profile of David J Morgans Jr including associated specialties, affiliations and a list of published articles.
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5
Citations
226
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0
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Recent Articles
1.
Ullman J, Mellem K, Xi Y, Ramanan V, Merritt H, Choy R, et al.
Sci Transl Med
. 2024 Jan;
16(730):eadf1691.
PMID: 38232139
Glycogen synthase 1 (GYS1), the rate-limiting enzyme in muscle glycogen synthesis, plays a central role in energy homeostasis and has been proposed as a therapeutic target in multiple glycogen storage...
2.
Collibee S, Bergnes G, Muci A, Browne 4th W, Garard M, Hinken A, et al.
ACS Med Chem Lett
. 2018 Apr;
9(4):354-358.
PMID: 29670700
The identification and optimization of the first activators of fast skeletal muscle are reported. Compound was identified from high-throughput screening (HTS) and subsequently found to improve muscle function via interaction...
3.
Morgan B, Muci A, Lu P, Qian X, Tochimoto T, Smith W, et al.
ACS Med Chem Lett
. 2014 Jun;
1(9):472-7.
PMID: 24900233
We report the design, synthesis, and optimization of the first, selective activators of cardiac myosin. Starting with a poorly soluble, nitro-aromatic hit compound (1), potent, selective, and soluble myosin activators...
4.
Qian X, McDonald A, Zhou H, Adams N, Parrish C, Duffy K, et al.
ACS Med Chem Lett
. 2014 Jun;
1(1):30-4.
PMID: 24900171
Inhibition of mitotic kinesins represents a novel approach for the discovery of a new generation of anti-mitotic cancer chemotherapeutics. We report here the discovery of the first potent and selective...
5.
Wood K, Lad L, Luo L, Qian X, Knight S, Nevins N, et al.
Proc Natl Acad Sci U S A
. 2010 Feb;
107(13):5839-44.
PMID: 20167803
Centromere-associated protein-E (CENP-E) is a kinetochore-associated mitotic kinesin that is thought to function as the key receptor responsible for mitotic checkpoint signal transduction after interaction with spindle microtubules. We have...