David J Loane
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Explore the profile of David J Loane including associated specialties, affiliations and a list of published articles.
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83
Citations
5768
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Recent Articles
1.
Alves M, de Diego-Garcia L, Vegliante G, Moreno O, Gil B, Ramos-Cabrer P, et al.
Theranostics
. 2025 Jan;
15(4):1399-1419.
PMID: 39886340
Post-traumatic epilepsy (PTE) is one of the most common life-quality reducing consequences of traumatic brain injury (TBI). However, to date there are no pharmacological approaches to predict or to prevent...
2.
Wofford K, Browne K, Loane D, Meaney D, Cullen D
J Neuroinflammation
. 2024 Dec;
21(1):324.
PMID: 39696519
Traumatic brain injury (TBI) is a global health problem affecting millions of individuals annually, potentially resulting in persistent neuropathology, chronic neurological deficits, and death. However, TBI not only affects neural...
3.
Lisi I, Moro F, Mazzone E, Marklund N, Pischiutta F, Kobeissy F, et al.
Brain
. 2024 Nov;
PMID: 39514789
Rodent models are important research tools for studying the pathophysiology of traumatic brain injury (TBI) and developing new therapeutic interventions for this devastating neurological disorder. However, the failure rate for...
4.
Li L, Kodosaki E, Heslegrave A, Zetterberg H, Graham N, Zimmerman K, et al.
Brain
. 2024 Sep;
148(3):1015-1030.
PMID: 39323289
Pathophysiology and outcomes after traumatic brain injury (TBI) are complex and heterogeneous. Current classifications are uninformative about pathophysiology. Proteomic approaches with fluid-based biomarkers are ideal for exploring complex disease mechanisms,...
5.
Ritzel R, Li Y, Jiao Y, Doran S, Khan N, Henry R, et al.
J Neuroinflammation
. 2024 Apr;
21(1):83.
PMID: 38581043
Background: It is well established that traumatic brain injury (TBI) causes acute and chronic alterations in systemic immune function and that systemic immune changes contribute to posttraumatic neuroinflammation and neurodegeneration....
6.
7.
Gandasasmita N, Li J, Loane D, Semple B
J Neurotrauma
. 2023 Oct;
41(7-8):752-770.
PMID: 37885226
Patients hospitalized after a moderate or severe traumatic brain injury (TBI) are at increased risk of nosocomial infections, including bacterial pneumonia and other upper respiratory tract infections. Infections represent a...
8.
Ritzel R, Li Y, Jiao Y, Doran S, Khan N, Henry R, et al.
Res Sq
. 2023 Oct;
PMID: 37790560
Traumatic brain injury (TBI) causes acute and chronic alterations in systemic immune function which contribute to posttraumatic neuroinflammation and neurodegeneration. However, how TBI affects bone marrow (BM) hematopoietic stem/progenitor cells...
9.
Strogulski N, Portela L, Polster B, Loane D
J Neurochem
. 2023 Sep;
167(2):129-153.
PMID: 37759406
Traumatic brain injury (TBI) is a devastating neurological disorder caused by a physical impact to the brain that promotes diffuse damage and chronic neurodegeneration. Key mechanisms believed to support secondary...
10.
Makarava N, Mychko O, Molesworth K, Chang J, Henry R, Tsymbalyuk N, et al.
Cells
. 2023 Sep;
12(17).
PMID: 37681904
The transformation of astrocytes into reactive states constitutes a biological response of the central nervous system under a variety of pathological insults. Astrocytes display diverse homeostatic identities that are developmentally...