David J Hinrichs
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Explore the profile of David J Hinrichs including associated specialties, affiliations and a list of published articles.
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28
Citations
617
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Recent Articles
1.
Smilkstein M, Pou S, Krollenbrock A, Bleyle L, Dodean R, Frueh L, et al.
Malar J
. 2019 Aug;
18(1):291.
PMID: 31455339
Background: The potential benefits of long-acting injectable chemoprotection (LAI-C) against malaria have been recently recognized, prompting a call for suitable candidate drugs to help meet this need. On the basis...
2.
Lawres L, Garg A, Kumar V, Bruzual I, Forquer I, Renard I, et al.
J Exp Med
. 2016 Jun;
213(7):1307-18.
PMID: 27270894
Human babesiosis is a tick-borne multisystem disease caused by Babesia species of the apicomplexan phylum. Most clinical cases and fatalities of babesiosis are caused by Babesia microti Current treatment for...
3.
Stickles A, Ting L, Morrisey J, Li Y, Mather M, Meermeier E, et al.
Am J Trop Med Hyg
. 2015 Apr;
92(6):1195-201.
PMID: 25918204
Single-dose therapies for malaria have been proposed as a way to reduce the cost and increase the effectiveness of antimalarial treatment. However, no compound to date has shown single-dose activity...
4.
Archie Bouwer H, Gregory C, Wegmann K, Hinrichs D
J Neuroimmunol
. 2014 Dec;
278:194-9.
PMID: 25468271
Animals that have recovered from adoptively transferred EAE develop clinical disease signs 2-3days earlier than controls when challenged with encephalitogen. This may be due to the reactivation of donor-derived memory...
5.
Wegmann K, Archie Bouwer H, Whitham R, Hinrichs D
J Neuroimmunol
. 2014 Jul;
274(1-2):46-52.
PMID: 24997489
We have used a peptide derived from Acanthamoeba castellanii (ACA) to treat the relapsing phase of EAE that develops in SJL mice following immunization with the PLP 139-151 peptide. The...
6.
Nilsen A, Miley G, Forquer I, Mather M, Katneni K, Li Y, et al.
J Med Chem
. 2014 Apr;
57(9):3818-34.
PMID: 24720377
The historical antimalarial compound endochin served as a structural lead for optimization. Endochin-like quinolones (ELQ) were prepared by a novel chemical route and assessed for in vitro activity against multidrug...
7.
Janowsky A, Eshleman A, Johnson R, Wolfrum K, Hinrichs D, Yang J, et al.
Psychopharmacology (Berl)
. 2014 Feb;
231(14):2771-83.
PMID: 24488404
Rationale: Mefloquine is used for the prevention and treatment of chloroquine-resistant malaria, but its use is associated with nightmares, hallucinations, and exacerbation of symptoms of post-traumatic stress disorder. We hypothesized...
8.
Wegmann K, Archie Bouwer H, Gregory C, Whitham R, Hinrichs D
J Neuroimmunol
. 2013 Apr;
260(1-2):74-81.
PMID: 23611642
Upon recovery from the initial episode of experimental autoimmune encephalomyelitis (EAE), virtually all SJL mice develop relapsing/remitting episodes of disease. These relapses may occur due to the reactivation of memory...
9.
Doggett J, Nilsen A, Forquer I, Wegmann K, Jones-Brando L, Yolken R, et al.
Proc Natl Acad Sci U S A
. 2012 Sep;
109(39):15936-41.
PMID: 23019377
Toxoplasma gondii is a widely distributed protozoan pathogen that causes devastating ocular and central nervous system disease. We show that the endochin-like quinolone (ELQ) class of compounds contains extremely potent...
10.
Pou S, Winter R, Nilsen A, Kelly J, Li Y, Doggett J, et al.
Antimicrob Agents Chemother
. 2012 Apr;
56(7):3475-80.
PMID: 22508305
Sontochin was the original chloroquine replacement drug, arising from research by Hans Andersag 2 years after chloroquine (known as "resochin" at the time) had been shelved due to the mistaken...