David J Duffy
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Explore the profile of David J Duffy including associated specialties, affiliations and a list of published articles.
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33
Citations
473
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Recent Articles
11.
Whitmore L, Yetsko K, Farrell J, Page-Karjian A, Daniel W, Shaver D, et al.
Animals (Basel)
. 2021 Sep;
11(9).
PMID: 34573455
The spreading global sea turtle fibropapillomatosis (FP) epizootic is threatening some of Earth's ancient reptiles, adding to the plethora of threats faced by these keystone species. Understanding this neoplastic disease...
12.
Farrell J, Yetsko K, Whitmore L, Whilde J, Eastman C, Rollinson Ramia D, et al.
Commun Biol
. 2021 May;
4(1):565.
PMID: 33980988
Pathogen-induced cancers account for 15% of human tumors and are a growing concern for endangered wildlife. Fibropapillomatosis is an expanding virally and environmentally co-induced sea turtle tumor epizootic. Chelonid herpesvirus...
13.
Krstic A, Konietzny A, Halasz M, Cain P, Oppermann U, Kolch W, et al.
Front Cell Dev Biol
. 2021 May;
9:612518.
PMID: 33968920
Although a rare disease, neuroblastoma accounts for the highest proportion of childhood cancer deaths. There is a lack of recurrent somatic mutations in neuroblastoma embryonal tumours, suggesting a possible role...
14.
Yetsko K, Farrell J, Blackburn N, Whitmore L, Stammnitz M, Whilde J, et al.
Commun Biol
. 2021 Feb;
4(1):152.
PMID: 33526843
Sea turtle populations are under threat from an epizootic tumor disease (animal epidemic) known as fibropapillomatosis. Fibropapillomatosis continues to spread geographically, with prevalence of the disease also growing at many...
15.
16.
Duffy D, Martindale M
Commun Biol
. 2019 Feb;
2:54.
PMID: 30775456
Our recent Communications Biology research article revealed the genomic drivers and therapeutic vulnerabilities of sea turtle fibropapillomatosis tumors. Fibropapillomatosis is a debilitating tumorous disease afflicting populations of green sea turtles...
17.
Duffy D, Schnitzler C, Karpinski L, Thomas R, Whilde J, Eastman C, et al.
Commun Biol
. 2018 Oct;
1:63.
PMID: 30271945
Wildlife populations are under intense anthropogenic pressures, with the geographic range of many species shrinking, dramatic reductions in population numbers and undisturbed habitats, and biodiversity loss. It is postulated that...
18.
Daly C, Shine L, Heffernan T, Deeti S, Reynolds A, OConnor J, et al.
Sci Rep
. 2017 Sep;
7(1):11320.
PMID: 28900183
Controversially, histone deacetylase inhibitors (HDACi) are in clinical trial for the treatment of inherited retinal degeneration. Utilizing the zebrafish dye model, we determined if treatment with HDACi can rescue cone...
19.
Duffy D, Krstic A, Halasz M, Schwarzl T, Konietzny A, Iljin K, et al.
Genome Med
. 2017 Feb;
9(1):15.
PMID: 28187790
Background: Retinoid therapy is widely employed in clinical oncology to differentiate malignant cells into their more benign counterparts. However, certain high-risk cohorts, such as patients with MYCN-amplified neuroblastoma, are innately...
20.
Whilde J, Martindale M, Duffy D
Glob Chang Biol
. 2016 Nov;
23(5):1792-1805.
PMID: 27809394
The current species extinction crisis is being exacerbated by an increased rate of emergence of epizootic disease. Human-induced factors including habitat degradation, loss of biodiversity and wildlife population reductions resulting...