David Heckerman
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Explore the profile of David Heckerman including associated specialties, affiliations and a list of published articles.
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11097
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Recent Articles
1.
Doll M, Waghmare A, Heit A, Levenson Shakoor B, Kimball L, Ozbek N, et al.
JAMA Netw Open
. 2023 Feb;
6(2):e231181.
PMID: 36853602
Importance: The US arrival of the Omicron variant led to a rapid increase in SARS-CoV-2 infections. While numerous studies report characteristics of Omicron infections among vaccinated individuals or persons with...
2.
Doll M, Waghmare A, Heit A, Levenson Shakoor B, Kimball L, Ozbek N, et al.
medRxiv
. 2022 Nov;
PMID: 36425923
Importance: The U.S. arrival of the Omicron variant led to a rapid increase in SARS-CoV-2 infections. While numerous studies report characteristics of Omicron infections among vaccinated individuals and/or persons with...
3.
Souza G, Van Sluys M, Lembke C, Lee H, Margarido G, Hotta C, et al.
Gigascience
. 2019 Nov;
8(12).
PMID: 31782791
Background: Sugarcane cultivars are polyploid interspecific hybrids of giant genomes, typically with 10-13 sets of chromosomes from 2 Saccharum species. The ploidy, hybridity, and size of the genome, estimated to...
4.
Wells A, Heckerman D, Torkamani A, Yin L, Sebat J, Ren B, et al.
Nat Commun
. 2019 Nov;
10(1):5241.
PMID: 31748530
A gene is considered essential if loss of function results in loss of viability, fitness or in disease. This concept is well established for coding genes; however, non-coding regions are...
5.
Gurdasani D, Carstensen T, Fatumo S, Chen G, Franklin C, Prado-Martinez J, et al.
Cell
. 2019 Nov;
179(4):984-1002.e36.
PMID: 31675503
Genomic studies in African populations provide unique opportunities to understand disease etiology, human diversity, and population history. In the largest study of its kind, comprising genome-wide data from 6,400 individuals...
6.
Zhang J, Zhang X, Tang H, Zhang Q, Hua X, Ma X, et al.
Nat Genet
. 2018 Nov;
50(12):1754.
PMID: 30425353
In the version of this article originally published, the accession codes listed in the data availability section were incorrect and the section was incomplete. The text for this section should...
7.
Zhang J, Zhang X, Tang H, Zhang Q, Hua X, Ma X, et al.
Nat Genet
. 2018 Oct;
50(11):1565-1573.
PMID: 30297971
Modern sugarcanes are polyploid interspecific hybrids, combining high sugar content from Saccharum officinarum with hardiness, disease resistance and ratooning of Saccharum spontaneum. Sequencing of a haploid S. spontaneum, AP85-441, facilitated...
8.
Lee S, Gornitz N, Xing E, Heckerman D, Lippert C
IEEE Trans Pattern Anal Mach Intell
. 2018 Jul;
40(12):2841-2852.
PMID: 29989981
In order to solve large-scale lasso problems, screening algorithms have been developed that discard features with zero coefficients based on a computationally efficient screening rule. Most existing screening rules were...
9.
Heckerman D, Traynor B, Picca A, Calvani R, Marzetti E, Hernandez D, et al.
Sci Rep
. 2017 Nov;
7(1):15879.
PMID: 29158487
Unraveling the complexity of aging is crucial for understanding its mechanisms and its role as a risk factor for most chronic conditions. Advancements marked by genome-wide association studies (GWASs) have...
10.
Tang H, Kirkness E, Lippert C, Biggs W, Fabani M, Guzman E, et al.
Am J Hum Genet
. 2017 Nov;
101(5):700-715.
PMID: 29100084
Short tandem repeats (STRs) are hyper-mutable sequences in the human genome. They are often used in forensics and population genetics and are also the underlying cause of many genetic diseases....