David H Margulies
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Explore the profile of David H Margulies including associated specialties, affiliations and a list of published articles.
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70
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1260
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Recent Articles
1.
Jiang J, Natarajan K, Margulies D
IUCrJ
. 2024 Apr;
11(Pt 3):287-298.
PMID: 38656309
This work focuses on molecules that are encoded by the major histocompatibility complex (MHC) and that bind self-, foreign- or tumor-derived peptides and display these at the cell surface for...
2.
Boyd L, Jiang J, Ahmad J, Natarajan K, Margulies D
J Immunol
. 2024 Mar;
212(8):1366-1380.
PMID: 38456672
mAbs to MHC class I (MHC-I) molecules have proved to be crucial reagents for tissue typing and fundamental studies of immune recognition. To augment our understanding of epitopic sites seen...
3.
Boyd L, Jiang J, Ahmad J, Natarajan K, Margulies D
bioRxiv
. 2023 Dec;
PMID: 38106040
Monoclonal antibodies (mAb) to major histocompatibility complex class I (MHC-I) molecules have proved to be crucial reagents for tissue typing and fundamental studies of immune recognition. To augment our understanding...
4.
Jiang J, Boughter C, Ahmad J, Natarajan K, Boyd L, Meier-Schellersheim M, et al.
Commun Biol
. 2023 Sep;
6(1):953.
PMID: 37726484
The COVID-19 pandemic and SARS-CoV-2 variants have dramatically illustrated the need for a better understanding of antigen (epitope)-antibody (paratope) interactions. To gain insight into the immunogenic characteristics of epitopic sites...
5.
Margulies D, Jiang J, Ahmad J, Boyd L, Natarajan K
Front Immunol
. 2023 Jul;
14:1179846.
PMID: 37398669
Peptide loading of MHC-I molecules plays a critical role in the T cell response to infections and tumors as well as to interactions with inhibitory receptors on natural killer (NK)...
6.
Jiang J, Boughter C, Ahmad J, Natarajan K, Boyd L, Meier-Schellersheim M, et al.
Res Sq
. 2023 Jun;
PMID: 37333174
The COVID-19 pandemic and SARS-CoV-2 variants have dramatically illustrated the need for a better understanding of antigen (epitope)-antibody (paratope) interactions. To gain insight into the immunogenic characteristics of epitopic sites...
7.
Chen Z, Zhang P, Matsuoka Y, Tsybovsky Y, West K, Santos C, et al.
Cell Rep
. 2022 Oct;
41(5):111528.
PMID: 36302375
The emergence and global spread of the SARS-CoV-2 Omicron variants, which carry an unprecedented number of mutations, raise serious concerns due to the reduced efficacy of current vaccines and resistance...
8.
Jiang J, Taylor D, Kim E, Boyd L, Ahmad J, Mage M, et al.
Nat Commun
. 2022 Sep;
13(1):5470.
PMID: 36115831
Loading of MHC-I molecules with peptide by the catalytic chaperone tapasin in the peptide loading complex plays a critical role in antigen presentation and immune recognition. Mechanistic insight has been...
9.
Margulies D, Taylor D, Jiang J, Boyd L, Ahmad J, Mage M, et al.
Front Immunol
. 2022 Apr;
13:859782.
PMID: 35464465
Immune recognition by T lymphocytes and natural killer (NK) cells is in large part dependent on the identification of cell surface MHC molecules bearing peptides generated from either endogenous (MHC...
10.
Chen Z, Zhang P, Matsuoka Y, Tsybovsky Y, West K, Santos C, et al.
medRxiv
. 2022 Jan;
PMID: 35043120
The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has triggered a devastating global health, social and economic crisis. The RNA nature and...