David H Hawke
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Explore the profile of David H Hawke including associated specialties, affiliations and a list of published articles.
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64
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3704
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Recent Articles
1.
Fu J, Ling J, Li C, Tsai C, Yin W, Hou J, et al.
Nat Commun
. 2024 Apr;
15(1):3149.
PMID: 38605037
Pancreatic ductal adenocarcinoma (PDAC) develops through step-wise genetic and molecular alterations including Kras mutation and inactivation of various apoptotic pathways. Here, we find that development of apoptotic resistance and metastasis...
2.
Tan T, Wu C, Liu B, Pan B, Hawke D, Su Z, et al.
Mol Biol Cell
. 2022 Aug;
33(12):ar115.
PMID: 35976701
The term M-phase supershift denotes the phosphorylation-dependent substantial increase in the apparent molecular weight of numerous proteins of varied biological functions during M-phase induction. Although the M-phase supershift of multiple...
3.
Li Y, Zhang Y, Hu Q, Egranov S, Xing Z, Zhang Z, et al.
Genome Med
. 2021 Aug;
13(1):137.
PMID: 34454586
Background: Exercise training is well established as the most effective way to enhance muscle performance and muscle building. The composition of skeletal muscle fiber type affects systemic energy expenditures, and...
4.
Li Y, Tan Z, Zhang Y, Zhang Z, Hu Q, Liang K, et al.
Science
. 2021 Aug;
373(6555):662-673.
PMID: 34353949
The functional role of long noncoding RNAs (lncRNAs) in inherited metabolic disorders, including phenylketonuria (PKU), is unknown. Here, we demonstrate that the mouse lncRNA and human associate with phenylalanine hydroxylase...
5.
Zhang Y, Li Y, Hu Q, Xi Y, Xing Z, Zhang Z, et al.
Nat Cell Biol
. 2020 Oct;
22(11):1332-1345.
PMID: 33106653
Dystrophin proteomic regulation in muscular dystrophies (MDs) remains unclear. We report that a long noncoding RNA (lncRNA), H19, associates with dystrophin and inhibits E3-ligase-dependent polyubiquitination at Lys 3584 (referred to...
6.
Petchampai N, Isoe J, Horvath T, Dagan S, Tan L, Lorenzi P, et al.
Insect Biochem Mol Biol
. 2020 Apr;
121:103366.
PMID: 32276114
A recent in vitro characterization of a recombinant pyruvate kinase (PK) from Aedes aegypti mosquitoes demonstrated that the enzyme is uniquely regulated by multiple allosteric effectors. Here, we further explored...
7.
Yu-Lee L, Lee Y, Pan J, Lin S, Pan T, Yu G, et al.
Sci Rep
. 2019 Dec;
9(1):18635.
PMID: 31819067
Disseminated tumor cells (DTCs) undergo a dormant state in the distant metastatic site(s) before becoming overt metastatic diseases. In prostate cancer (PCa), bone metastasis can occur years after prostatectomy, suggesting...
8.
Hu Q, Ye Y, Chan L, Li Y, Liang K, Lin A, et al.
Nat Immunol
. 2019 Jun;
20(7):835-851.
PMID: 31160797
How tumor cells genetically lose antigenicity and evade immune checkpoints remains largely elusive. We report that tissue-specific expression of the human long noncoding RNA LINK-A in mouse mammary glands initiates...
9.
Yang P, Jiang Y, Pan Y, Ding X, Rhea P, Ding J, et al.
Sci Rep
. 2019 Apr;
9(1):6428.
PMID: 31015523
Mistletoe (Viscum album) is a type of parasitic plant reported to have anticancer activity including in hepatocellular carcinoma (HCC). However, the mechanism of mistletoe's anticancer activity, and its effectiveness in...
10.
Li Y, Hu Q, Li C, Liang K, Xiang Y, Hsiao H, et al.
J Clin Invest
. 2019 Feb;
129(3):1129-1151.
PMID: 30741721
Epithelial-mesenchymal transition (EMT) contributes significantly to interstitial matrix deposition in diabetic kidney disease (DKD). However, detection of EMT in kidney tissue is impracticable, and anti-EMT therapies have long been hindered....