David H Farrell
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Explore the profile of David H Farrell including associated specialties, affiliations and a list of published articles.
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35
Citations
389
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Recent Articles
1.
Farrell D, McConnell K, Zilberman-Rudenko J, Behrens B, Mcloud S, Cook M, et al.
JAMA Netw Open
. 2024 Aug;
7(8):e2427786.
PMID: 39145978
Importance: Patients with trauma exhibit a complex balance of coagulopathy manifested by both bleeding and thrombosis. Antithrombin III is a plasma protein that functions as an important regulator of coagulation....
2.
Hudkins M, Hamilton H, Underwood S, Kazmierczak D, Dewey E, Kazmierczak S, et al.
Blood Cells Mol Dis
. 2024 May;
107:102856.
PMID: 38762921
COVID-19 disease progression can be accompanied by a "cytokine storm" that leads to secondary sequelae such as acute respiratory distress syndrome. Several inflammatory cytokines have been associated with COVID-19 disease...
3.
Kornblith L, Sadhanandhan B, Arun S, Long R, Johnson A, Noll J, et al.
Blood Cells Mol Dis
. 2024 Jan;
105:102825.
PMID: 38278055
No abstract available.
4.
Kornblith L, Sadhanandhan B, Arun S, Long R, Johnson A, Noll J, et al.
Blood Cells Mol Dis
. 2023 May;
101:102746.
PMID: 37150704
Coronavirus disease 2019 (COVID-19) is characterized by a pro-inflammatory state associated with organ failure, thrombosis, and death. We investigated a novel inflammatory biomarker, γ' fibrinogen (GPF), in 103 hospitalized patients...
5.
Kornblith L, Sadhanandhan B, Arun S, Long R, Johnson A, Noll J, et al.
Res Sq
. 2022 Oct;
PMID: 36299432
Coronavirus disease 2019 (COVID-19) is characterized by a pro-inflammatory state associated with organ failure, thrombosis, and death. We investigated a novel inflammatory biomarker, γ' fibrinogen (GPF), in 103 hospitalized patients...
6.
Anderson T, Farrell D, Rowell S
Semin Thromb Hemost
. 2021 Apr;
47(5):527-537.
PMID: 33878779
Posttraumatic coagulopathy involves disruption of both the coagulation and fibrinolytic pathways secondary to tissue damage, hypotension, and inflammatory upregulation. This phenomenon contributes to delayed complications after traumatic brain injury (TBI),...
7.
Dixon A, McCully B, Rick E, Dewey E, Farrell D, Morrison L, et al.
J Trauma Acute Care Surg
. 2020 Oct;
89(5):900-907.
PMID: 33105308
Background: No Food and Drug Administration-approved medication improves outcomes following traumatic brain injury (TBI). A forthcoming clinical trial that evaluated the effects of two prehospital tranexamic acid (TXA) dosing strategies...
8.
Farrell D, Rick E, Dewey E, Schreiber M, Rowell S
Am J Surg
. 2020 Jan;
220(2):459-463.
PMID: 31948701
Background: γ' fibrinogen is an alternatively-spliced fibrinogen variant that displays different coagulation parameters in vitro than the major form of fibrinogen. Purified γ' fibrinogen has slower clotting kinetics than unfractionated...
9.
Fair K, Farrell D, McCully B, Rick E, Dewey E, Hilliard C, et al.
J Neurotrauma
. 2019 Aug;
38(8):960-966.
PMID: 31382848
Progression of intracranial hemorrhage (PICH) is a significant cause of secondary brain injury in patients with traumatic brain injury (TBI). Previous studies have implicated a variety of mediators that contribute...
10.
Carvalho F, Guedes A, Duval C, Macrae F, Swithenbank L, Farrell D, et al.
Int J Nanomedicine
. 2018 Apr;
13:1985-1992.
PMID: 29662311
Background: Erythrocyte aggregation, a cardiovascular risk factor, is increased by high plasma fibrinogen levels. Here, the effect of different fibrinogen mutations on binding to its human erythrocyte receptor was assessed...