David Goulding
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Explore the profile of David Goulding including associated specialties, affiliations and a list of published articles.
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98
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5432
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Recent Articles
1.
Goulding D, Tolley C, Mkandawire T, Doyle S, Hart E, Airs P, et al.
PLoS Pathog
. 2025 Jan;
21(1):e1012502.
PMID: 39869639
Whipworms (Trichuris spp) are ubiquitous parasites of humans and domestic and wild mammals that cause chronic disease, considerably impacting human and animal health. Egg hatching is a critical phase in...
2.
Baker S, Krishna A, Higham S, Naydenova P, OLeary S, Scott J, et al.
Nat Commun
. 2024 Sep;
15(1):7979.
PMID: 39266557
The use of monoclonal antibodies for the control of drug resistant nosocomial bacteria may alleviate a reliance on broad spectrum antimicrobials for treatment of infection. We identify monoclonal antibodies that...
3.
Grillova L, Romeis E, Lieberman N, Tantalo L, Xu L, Molini B, et al.
Mol Microbiol
. 2024 Aug;
122(4):455-464.
PMID: 39115038
The recently discovered methodologies to cultivate and genetically manipulate Treponema pallidum subsp. pallidum (T. pallidum) have significantly helped syphilis research, allowing the in vitro evaluation of antibiotic efficacy, performance of...
4.
Bright New Resources for Syphilis Research: Genetically Encoded Fluorescent Tags for and Sf1Ep Cells
Grillova L, Romeis E, Lieberman N, Tantalo L, Xu L, Molini B, et al.
bioRxiv
. 2024 Jun;
PMID: 38854070
Graphical Abstract: By employing genetic engineering, was modified to express GFP, and Sf1Ep cells to express mCherry on the cytoplasmic membrane and BFP in the nucleus. These new resources for...
5.
Kioko M, Pance A, Mwangi S, Goulding D, Kemp A, Rono M, et al.
Nat Commun
. 2023 Oct;
14(1):6447.
PMID: 37833314
Plasmodium falciparum secretes extracellular vesicles (PfEVs) that contain parasite-derived RNA. However, the significance of the secreted RNA remains unexplored. Here, we compare secreted and intracellular RNA from asexual cultures of...
6.
Duque-Correa M, Goulding D, Rodgers F, Gillis J, Cormie C, Rawlinson K, et al.
Nat Commun
. 2022 Apr;
13(1):1725.
PMID: 35365634
Whipworms are large metazoan parasites that inhabit multi-intracellular epithelial tunnels in the large intestine of their hosts, causing chronic disease in humans and other mammals. How first-stage larvae invade host...
7.
Host adaptation in gut Firmicutes is associated with sporulation loss and altered transmission cycle
Browne H, Almeida A, Kumar N, Vervier K, Adoum A, Viciani E, et al.
Genome Biol
. 2021 Aug;
22(1):204.
PMID: 34348764
Background: Human-to-human transmission of symbiotic, anaerobic bacteria is a fundamental evolutionary adaptation essential for membership of the human gut microbiota. However, despite its importance, the genomic and biological adaptations underpinning...
8.
Bianchi E, Sun Y, Almansa-Ordonez A, Woods M, Goulding D, Martinez-Martin N, et al.
Nat Commun
. 2021 Feb;
12(1):1251.
PMID: 33623007
Dysfunction of embryo transport causes ectopic pregnancy which affects approximately 2% of conceptions in the US and Europe, and is the most common cause of pregnancy-related death in the first...
9.
Duque-Correa M, Schreiber F, Rodgers F, Goulding D, Forrest S, White R, et al.
Int J Parasitol
. 2020 Jul;
50(9):707-718.
PMID: 32659277
The caecum, an intestinal appendage in the junction of the small and large intestines, displays a unique epithelium that serves as an exclusive niche for a range of pathogens including...
10.
Rawlinson K, Lapraz F, Ballister E, Terasaki M, Rodgers J, McDowell R, et al.
Elife
. 2019 Oct;
8.
PMID: 31635694
Animals detect light using opsin photopigments. Xenopsin, a recently classified subtype of opsin, challenges our views on opsin and photoreceptor evolution. Originally thought to belong to the Gαi-coupled ciliary opsins,...