David Goricanec
Overview
Explore the profile of David Goricanec including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
119
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0
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Recent Articles
1.
Mohamadi M, Goricanec D, Wagner G, Hagn F
J Struct Biol
. 2023 May;
215(2):107970.
PMID: 37142193
G protein-coupled receptors (GPCRs) are involved in a multitude of cellular signaling cascades and consequently are a prominent target for pharmaceutical drugs. In the past decades, a growing number of...
2.
Goba I, Goricanec D, Schum D, Hillenbrand M, Pluckthun A, Hagn F
Chembiochem
. 2020 Sep;
22(1):139-146.
PMID: 32881260
G protein-coupled receptors (GPCRs) are key players in mediating signal transduction across the cell membrane. However, due to their intrinsic instability, many GPCRs are not suitable for structural investigations. Various...
3.
Goricanec D, Hagn F
Biomol NMR Assign
. 2018 Dec;
13(1):131-137.
PMID: 30539422
G-proteins are essential switch points at the cell membrane that control downstream signaling by their ability to adopt an inactive, GDP-bound or an active, GTP-bound state. Among other exchange factors,...
4.
Miehling J, Goricanec D, Hagn F
Chembiochem
. 2018 Jun;
19(18):1927-1933.
PMID: 29947468
Phospholipid nanodiscs are a native-like membrane mimetic that is suitable for structural studies of membrane proteins. Although nanodiscs of different sizes exist for various structural applications, their thermal and long-term...
5.
Rodriguez Camargo D, Korshavn K, Jussupow A, Raltchev K, Goricanec D, Fleisch M, et al.
Elife
. 2017 Nov;
6.
PMID: 29148426
Membrane-assisted amyloid formation is implicated in human diseases, and many of the aggregating species accelerate amyloid formation and induce cell death. While structures of membrane-associated intermediates would provide tremendous insights...
6.
Goricanec D, Stehle R, Egloff P, Grigoriu S, Pluckthun A, Wagner G, et al.
Proc Natl Acad Sci U S A
. 2016 Jun;
113(26):E3629-38.
PMID: 27298341
Heterotrimeric G proteins play a pivotal role in the signal-transduction pathways initiated by G-protein-coupled receptor (GPCR) activation. Agonist-receptor binding causes GDP-to-GTP exchange and dissociation of the Gα subunit from the...