Axel Karl Walch
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Explore the profile of Axel Karl Walch including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
237
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Recent Articles
1.
Mateska I, Witt A, Hagag E, Sinha A, Yilmaz C, Thanou E, et al.
Elife
. 2023 Jul;
12.
PMID: 37449973
The hypothalamus-pituitary-adrenal (HPA) axis is activated in response to inflammation leading to increased production of anti-inflammatory glucocorticoids by the adrenal cortex, thereby representing an endogenous feedback loop. However, severe inflammation...
2.
Maier J, Ravi V, Kueckelhaus J, Behringer S, Garrelfs N, Will P, et al.
Cell Death Dis
. 2021 Jul;
12(8):723.
PMID: 34290229
Glioblastoma (GBM), the most malignant tumor of the central nervous system, is marked by its dynamic response to microenvironmental niches. In particular, this cellular plasticity contributes to the development of...
3.
Murakami M, Sun N, Greunke C, Feuchtinger A, Kircher S, Deutschbein T, et al.
Eur J Endocrinol
. 2021 May;
185(1):179-191.
PMID: 33983135
Objective: Within the past decade, important genetic drivers of pheochromocytoma and paraganglioma (PPGLs) development have been identified. The pathophysiological mechanism that translates these alterations into functional autonomy and potentially malignant...
4.
Murakami M, Rhayem Y, Kunzke T, Sun N, Feuchtinger A, Ludwig P, et al.
JCI Insight
. 2019 Sep;
4(17).
PMID: 31484828
Recent genetic examinations and multisteroid profiles have provided the basis for subclassification of aldosterone-producing adenomas (APAs). The objective of the current study was to produce a comprehensive, high-resolution mass spectrometry...
5.
Papathomas T, Sun N, Chortis V, Taylor A, Arlt W, Richter S, et al.
Histochem Cell Biol
. 2019 Feb;
151(3):201-216.
PMID: 30725173
Metabolic alterations have implications in a spectrum of tissue functions and disease. Aided by novel molecular biological and computational tools, our understanding of physiological and pathological processes underpinning endocrine and...
6.
Rodriguez Camargo D, Garg D, Buday K, Franko A, Rodriguez Camargo A, Schmidt F, et al.
Chem Commun (Camb)
. 2018 May;
54(43):5426-5429.
PMID: 29745410
In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP,...
7.
Rodriguez Camargo D, Korshavn K, Jussupow A, Raltchev K, Goricanec D, Fleisch M, et al.
Elife
. 2017 Nov;
6.
PMID: 29148426
Membrane-assisted amyloid formation is implicated in human diseases, and many of the aggregating species accelerate amyloid formation and induce cell death. While structures of membrane-associated intermediates would provide tremendous insights...
8.
Rodriguez Camargo D, Tripsianes K, Buday K, Franko A, Gobl C, Hartlmuller C, et al.
Sci Rep
. 2017 Mar;
7:44041.
PMID: 28287098
Type II diabetes (T2D) is characterized by diminished insulin production and resistance of cells to insulin. Among others, endoplasmic reticulum (ER) stress is a principal factor contributing to T2D and...
9.
Wittmann A, Grimm M, Scherthan H, Horsch M, Beckers J, Fuchs H, et al.
PLoS One
. 2016 Oct;
11(10):e0164298.
PMID: 27788151
Sphingolipids and the derived gangliosides have critical functions in spermatogenesis, thus mutations in genes involved in sphingolipid biogenesis are often associated with male infertility. We have generated a transgenic mouse...
10.
Bi Z, Merl-Pham J, Uehlein N, Zimmer I, Muhlhans S, Aichler M, et al.
J Proteomics
. 2015 Aug;
128:321-32.
PMID: 26248320
Plasma membrane intrinsic proteins (PIPs) are one subfamily of aquaporins that mediate the transmembrane transport of water. To reveal their function in poplar, we generated transgenic poplar plants in which...