David Gilot
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Explore the profile of David Gilot including associated specialties, affiliations and a list of published articles.
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58
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1398
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Recent Articles
1.
Doudnikoff C, Leclerc D, Angenard G, Gilot D, Coulouarn C, Mouriaux F
Mol Vis
. 2024 Apr;
30:160-166.
PMID: 38601020
Purpose: Uveal melanoma (UM) is a deadly cancer with limited therapeutic options. At advanced stages, UM cells metastasize almost exclusively into the liver, where targeting metastatic UM cells remain a...
2.
Papoutsoglou P, Pineau R, Leroux R, Louis C, LHaridon A, Foretek D, et al.
EMBO Rep
. 2024 Feb;
25(3):1022-1054.
PMID: 38332153
Cholangiocarcinoma is a devastating liver cancer characterized by high aggressiveness and therapy resistance, resulting in poor prognosis. Long non-coding RNAs and signals imposed by oncogenic pathways, such as transforming growth...
3.
Mary L, Leclerc D, Labalme A, Bellaud P, Mazaud-Guittot S, Dreano S, et al.
Genes (Basel)
. 2023 Feb;
14(2).
PMID: 36833200
Sexual development is a complex process relying on numerous genes. Disruptions in some of these genes are known to cause differences of sexual development (DSDs). Advances in genome sequencing allowed...
4.
Leclerc D, Goujon L, Jaillard S, Nouyou B, Cluzeau L, Damaj L, et al.
CRISPR J
. 2023 Jan;
6(1):17-31.
PMID: 36629845
Ganglioside-monosialic acid (GM1) gangliosidosis, a rare autosomal recessive disorder, is frequently caused by deleterious single nucleotide variants (SNVs) in gene. These variants result in reduced β-galactosidase (β-gal) activity, leading to...
5.
Neyroud A, Rudinger-Thirion J, Frugier M, Riley L, Bidet M, Akloul L, et al.
Eur J Hum Genet
. 2022 Nov;
31(4):453-460.
PMID: 36450801
Premature ovarian insufficiency (POI) affects 1 in 100 women and is a leading cause of female infertility. There are over 80 genes in which variants can cause POI, with these...
6.
Quemener A, Bachelot L, Aubry M, Avner S, Leclerc D, Salbert G, et al.
Life Sci Alliance
. 2022 Oct;
5(12).
PMID: 36202613
Uveal melanoma (UM), the most common primary intraocular tumor in adults, has been extensively characterized by omics technologies during the last 5 yr. Despite the discovery of gene signatures, the...
7.
Sundaram G, Bessede A, Gilot D, Staats Pires A, Sherman L, Brew B, et al.
Int J Tryptophan Res
. 2022 Aug;
15:11786469221118657.
PMID: 36004319
Background: The essential amino acid, tryptophan, is predominantly metabolised through the kynurenine pathway (KP) to generate kynurenine, an aryl-hydrocarbon receptor (AhR) pro-ligand that exerts its effects in a ligand-dependent manner....
8.
Tucker E, Gutfreund N, Belaud-Rotureau M, Gilot D, Brun T, Kline B, et al.
Hum Mutat
. 2022 Jul;
43(10):1443-1453.
PMID: 35801529
Premature ovarian insufficiency (POI) is a leading form of female infertility, characterised by menstrual disturbance and elevated follicle-stimulating hormone before age 40. It is highly heterogeneous with variants in over...
9.
Mary L, Leclerc D, Gilot D, Belaud-Rotureau M, Jaillard S
Hum Mutat
. 2022 Apr;
43(9):1125-1148.
PMID: 35451537
PBX1 is a highly conserved atypical homeodomain transcription factor (TF) belonging to the TALE (three amino acid loop extension) family. Dimerized with other TALE proteins, it can interact with numerous...
10.
Diazzi S, Baeri A, Fassy J, Lecacheur M, Marin-Bejar O, Girard C, et al.
EMBO Mol Med
. 2022 Feb;
14(3):e15295.
PMID: 35156321
Lineage dedifferentiation toward a mesenchymal-like state displaying myofibroblast and fibrotic features is a common mechanism of adaptive and acquired resistance to targeted therapy in melanoma. Here, we show that the...