David Gatfield
Overview
Explore the profile of David Gatfield including associated specialties, affiliations and a list of published articles.
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Articles
42
Citations
3696
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Recent Articles
1.
Meurs R, De Matos M, Bothe A, Guex N, Weber T, Teleman A, et al.
EMBO J
. 2025 Jan;
44(3):854-876.
PMID: 39748120
Ribosomes scanning from the mRNA 5' cap to the start codon may initiate at upstream open reading frames (uORFs), decreasing protein biosynthesis. Termination at a uORF can lead to re-initiation,...
2.
Nadimpalli H, Katsioudi G, Arpa E, Chikhaoui L, Arpat A, Liechti A, et al.
Genome Biol
. 2024 May;
25(1):128.
PMID: 38773499
Background: Cellular iron homeostasis is regulated by iron regulatory proteins (IRP1 and IRP2) that sense iron levels (and other metabolic cues) and modulate mRNA translation or stability via interaction with...
3.
Snieckute G, Ryder L, Vind A, Wu Z, Arendrup F, Stoneley M, et al.
Science
. 2023 Dec;
382(6675):eadf3208.
PMID: 38060659
The ribotoxic stress response (RSR) is a signaling pathway in which the p38- and c-Jun N-terminal kinase (JNK)-activating mitogen-activated protein kinase kinase kinase (MAP3K) ZAKα senses stalling and/or collision of...
4.
Saurer M, Leibundgut M, Nadimpalli H, Scaiola A, Schonhut T, Lee R, et al.
Science
. 2023 May;
380(6644):531-536.
PMID: 37141370
The genetic code that specifies the identity of amino acids incorporated into proteins during protein synthesis is almost universally conserved. Mitochondrial genomes feature deviations from the standard genetic code, including...
5.
Katsioudi G, Dreos R, Arpa E, Gaspari S, Liechti A, Sato M, et al.
Sci Adv
. 2023 Jan;
9(2):eade2828.
PMID: 36638184
Nonsense-mediated messenger RNA (mRNA) decay (NMD) has been intensively studied as a surveillance pathway that degrades erroneous transcripts arising from mutations or RNA processing errors. While additional roles in physiological...
6.
Snieckute G, Genzor A, Vind A, Ryder L, Stoneley M, Chamois S, et al.
Cell Metab
. 2022 Nov;
34(12):2036-2046.e8.
PMID: 36384144
Impairment of translation can lead to collisions of ribosomes, which constitute an activation platform for several ribosomal stress-surveillance pathways. Among these is the ribotoxic stress response (RSR), where ribosomal sensing...
7.
Schaefer M, Nabih A, Spies D, Hermes V, Bodak M, Wischnewski H, et al.
EMBO Rep
. 2022 Jul;
23(9):e54762.
PMID: 35899551
MicroRNA (miRNA) loaded Argonaute (AGO) complexes regulate gene expression via direct base pairing with their mRNA targets. Previous works suggest that up to 60% of mammalian transcripts might be subject...
8.
Katsioudi G, Osorio-Forero A, Sinturel F, Hagedorn C, Kreppel F, Schibler U, et al.
Methods Mol Biol
. 2022 May;
2482:217-242.
PMID: 35610430
There is high interest in investigating the daily dynamics of gene expression in mammalian organs, for example, in liver. Such studies help to elucidate how and with what kinetics peripheral...
9.
Gruhl F, Janich P, Kaessmann H, Gatfield D
Elife
. 2021 Sep;
10.
PMID: 34542406
Circular RNAs (circRNAs) are found across eukaryotes and can function in post-transcriptional gene regulation. Their biogenesis through a circle-forming backsplicing reaction is facilitated by reverse-complementary repetitive sequences promoting pre-mRNA folding....
10.
Simeoni M, Cavinato T, Rodriguez D, Gatfield D
Commun Biol
. 2021 Jun;
4(1):715.
PMID: 34112887
While SARS-CoV-2 is causing modern human history's most serious health crisis and upending our way of life, clinical and basic research on the virus is advancing rapidly, leading to fascinating...