David Gailani
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Explore the profile of David Gailani including associated specialties, affiliations and a list of published articles.
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152
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3740
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Recent Articles
1.
Shamanaev A, Ma Y, Ponczek M, Sun M, Cheng Q, Dickeson S, et al.
Blood Adv
. 2025 Jan;
PMID: 39883942
In plasma, the zymogens factor XII (FXII) and prekallikrein reciprocally convert each other to the proteases FXIIa and plasma kallikrein (PKa). PKa cleaves high-molecular-weight kininogen (HK) to release bradykinin, which...
2.
Hart S, Gailani D, Bibb L, Zwerner J, Booth G, Jacobs J
Am J Clin Pathol
. 2025 Jan;
PMID: 39883062
Objective: Hemostatic abnormalities, including disseminated intravascular coagulation (DIC), are often cited as a common finding in patients following Loxosceles spider envenomation (ie, loxoscelism). The prevalence and severity of coagulopathy, however,...
3.
Lira A, Taskin B, Puy C, Keshari R, Silasi R, Pang J, et al.
J Biol Chem
. 2024 Dec;
301(1):108110.
PMID: 39706265
Lipopolysaccharide (LPS) is the primary pathogenic factor in Gram-negative sepsis. While the presence of LPS in the bloodstream during infection is associated with disseminated intravascular coagulation, the mechanistic link between...
4.
Puy C, Moellmer S, Pang J, Vu H, Melrose A, Lorentz C, et al.
Blood
. 2024 Aug;
144(17):1821-1833.
PMID: 39158072
Loss of endothelial barrier function contributes to the pathophysiology of many inflammatory diseases. Coagulation factor XI (FXI) plays a regulatory role in inflammation. Although activation of FXI increases vascular permeability...
5.
Kohs T, Vu H, Jordan K, Parra-Izquierdo I, Hinds M, Shatzel J, et al.
Res Pract Thromb Haemost
. 2024 Jan;
8(1):102276.
PMID: 38226339
Background: Hyperlipidemia is associated with chronic inflammation and thromboinflammation. This is an underlying cause of several cardiovascular diseases, including atherosclerosis. In diseased blood vessels, rampant thrombin generation results in the...
6.
Clermont A, Murugesan N, Edwards H, Lee D, Bayliss N, Duckworth E, et al.
Front Pharmacol
. 2024 Jan;
14:1287487.
PMID: 38178859
The kallikrein kinin system (KKS) is an established pharmacological target for the treatment and prevention of attacks in hereditary angioedema (HAE). Proteolytic activities of FXIIa and single-chain Factor XII (FXII)...
7.
Gailani D, Gruber A
Blood
. 2023 Dec;
143(15):1465-1475.
PMID: 38142404
Direct oral anticoagulants (DOACs) that inhibit the coagulation proteases thrombin or factor Xa (FXa) have replaced warfarin and other vitamin K antagonists (VKAs) for most indications requiring long-term anticoagulation. In...
8.
Sharma M, Molina C, Toyoda K, Bereczki D, Bangdiwala S, Kasner S, et al.
Lancet Neurol
. 2023 Dec;
23(1):46-59.
PMID: 38101902
Background: People with factor XI deficiency have lower rates of ischaemic stroke than the general population and infrequent spontaneous bleeding, suggesting that factor XI has a more important role in...
9.
Dickeson S, Kumar S, Sun M, Litvak M, He T, Phillips D, et al.
Blood
. 2023 Nov;
143(7):641-650.
PMID: 37992228
Hereditary angioedema (HAE) is associated with episodic kinin-induced swelling of the skin and mucosal membranes. Most patients with HAE have low plasma C1-inhibitor activity, leading to increased generation of the...
10.
Pfeffer M, Kohs T, Vu H, Jordan K, Wang J, Lorentz C, et al.
Arterioscler Thromb Vasc Biol
. 2023 Nov;
44(1):290-299.
PMID: 37970718
Background: Despite the ubiquitous utilization of central venous catheters in clinical practice, their use commonly provokes thromboembolism. No prophylactic strategy has shown sufficient efficacy to justify routine use. Coagulation factors...