David G Harden
Overview
Explore the profile of David G Harden including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
14
Citations
113
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Miller M, Banville J, Friends T, Gagnon M, Hangeland J, Lavallee J, et al.
J Med Chem
. 2019 Jun;
62(16):7400-7416.
PMID: 31246024
In an effort to identify novel antithrombotics, we have investigated protease-activated receptor 4 (PAR4) antagonism by developing and evaluating a tool compound, , in a monkey thrombosis model. Beginning with...
2.
Duclos F, Abell L, Harden D, Pike K, Nowak K, Locke G, et al.
Medchemcomm
. 2018 Aug;
8(11):2093-2099.
PMID: 30108726
Myeloperoxidase, a mammalian peroxidase involved in the immune system as an anti-microbial first responder, can produce hypochlorous acid in response to invading pathogens. Myeloperoxidase has been implicated in several chronic...
3.
Brown J, Hunihan L, Prack M, Harden D, Bronson J, Dzierba C, et al.
J Neurochem
. 2013 Nov;
129(2):275-83.
PMID: 24266811
NMDA receptor hypofunction is hypothesized to contribute to cognitive deficits associated with schizophrenia. Since direct activation of NMDA receptors is associated with serious adverse effects, modulation of the NMDA co-agonists,...
4.
Appiah K, Blat Y, Robertson B, Pearce B, Pedicord D, Gentles R, et al.
J Biomol Screen
. 2013 Nov;
19(4):595-605.
PMID: 24241710
Recent genetic evidence suggests that the diacylglycerol lipase (DAGL-α) isoform is the major biosynthetic enzyme for the most abundant endocannabinoid, 2-arachidonoyl-glycerol (2-AG), in the central nervous system. Revelation of its...
5.
Wu Y, Conway C, Sun L, Machet F, Chen J, Chen P, et al.
Bioorg Med Chem Lett
. 2013 Sep;
23(22):6188-91.
PMID: 24070783
Acrylamide (S)-6, a potent and efficacious KCNQ2 (Kv7.2) opener, demonstrated significant activity in two models of neuropathic pain and in the formalin test, suggesting that KCNQ2 openers may be useful...
6.
Mcdonald I, Mate R, Zusi F, Huang H, Post-Munson D, Ferrante M, et al.
Bioorg Med Chem Lett
. 2013 Feb;
23(6):1684-8.
PMID: 23414838
High throughput screening led to the identification of a novel series of quinolone α7 nicotinic acetylcholine receptor (nAChR) agonists. Optimization of an HTS hit (1) led to 4-phenyl-1-(quinuclidin-3-ylmethyl)quinolin-2(1H)-one, which was...
7.
Gentles R, Hu S, Huang Y, Grant-Young K, Poss M, Andres C, et al.
Bioorg Med Chem Lett
. 2008 Oct;
18(20):5694-7.
PMID: 18824351
An exploratory SAR study on a series of potent, non-apamin-displacing 4-(aminomethylaryl)pyrazolopyrimidine K(Ca) channel blockers is described and their selectivity against K(Ca) channel subtypes is reported. The most potent analog, 5-chloro-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine...
8.
Gentles R, Grant-Young K, Hu S, Huang Y, Poss M, Andres C, et al.
Bioorg Med Chem Lett
. 2008 Sep;
18(19):5316-9.
PMID: 18774291
An initial SAR study on a series of apamin-displacing 2-aminothiazole K(Ca)2 channel blockers is described. Potent inhibitors such as N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (13) are disclosed, and for select members of the series,...
9.
Gilchrist 2nd M, Cacace A, Harden D
J Biomol Screen
. 2008 Jun;
13(6):486-93.
PMID: 18566482
Fluorescent detection of calcium mobilization has been used successfully to identify modulators of G-protein-coupled receptors (GPCRs); however, inherent issues with fluorescence may limit its potential for high-throughput screening miniaturization. The...
10.
Tertyshnikova S, Knox R, Plym M, Thalody G, Griffin C, Neelands T, et al.
J Pharmacol Exp Ther
. 2004 Dec;
313(1):250-9.
PMID: 15608074
BL-1249 [(5,6,7,8-tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine] produced a concentration-dependent membrane hyperpolarization of cultured human bladder myocytes, assessed as either a reduction in fluorescence of the voltage-sensitive dye bis-(1,2-dibutylbarbituric acid)trimethine oxonol (EC50 = 1.26 +/-...