David G Edwards
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Explore the profile of David G Edwards including associated specialties, affiliations and a list of published articles.
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102
Citations
1607
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Recent Articles
1.
Shenouda N, Stock J, Chouramanis N, Lincoln Z, Wenner M, Chirinos J, et al.
Am J Physiol Heart Circ Physiol
. 2025 Feb;
328(3):H648-H657.
PMID: 39925113
Increased arterial wave reflections can increase left ventricular wasted pressure effort (WPE) and cardiovascular disease risk. Naturally menstruating women experience fluctuations in sex hormones with known cardioprotective effects. We sought...
2.
Alam R, Reva A, Edwards D, Lege B, Munoz-Arcos L, Reduzzi C, et al.
Cancer Discov
. 2025 Jan;
PMID: 39835789
Bone metastases can disseminate to secondary sites and promote breast cancer progression creating additional clinical challenges. The mechanisms contributing to secondary metastasis are barely understood. Here, we evaluate the prediction...
3.
Nuckols V, Shoemaker L, Kuczmarski A, Haigh K, McGinty S, Del Vecchio A, et al.
Am J Physiol Heart Circ Physiol
. 2025 Jan;
328(2):H327-H332.
PMID: 39773019
The endothelin-B receptor (ETR) mediates vasodilation in young women, an effect that is absent in postmenopausal women. We have previously demonstrated that ETR-mediated vasodilation is regulated by estradiol (E) in...
4.
Wenner M, Shenouda N, Shoemaker L, Kuczmarski A, Haigh K, Del Vecchio A, et al.
Am J Physiol Heart Circ Physiol
. 2024 Oct;
327(5):H1286-H1295.
PMID: 39365671
Vascular dysfunction, marked by lower endothelial function and increased aortic stiffness, is a nontraditional risk factor that precedes the development of cardiovascular disease (CVD). However, the age at which these...
5.
Hao X, Shen Y, Liu J, Alexander A, Wu L, Xu Z, et al.
Nat Cell Biol
. 2024 Sep;
26(11):1971-1983.
PMID: 39266726
Solid tumours induce systemic immunosuppression that involves myeloid and T cells. B cell-related mechanisms remain relatively understudied. Here we discover two distinct patterns of tumour-induced B cell abnormality (TiBA; TiBA-1...
6.
Xu Z, Liu F, Ding Y, Pan T, Wu Y, Liu J, et al.
bioRxiv
. 2024 May;
PMID: 38765966
Highlights: SAMENT is a robust metastatic niche-labeling approach amenable to single-cell omics.Metastatic niches are typically enriched with macrophages and depleted of T cells.Direct interaction with cancer cells induces ERα expression...
7.
DeConne T, Fancher I, Edwards D, Trott D, Martens C
Am J Physiol Regul Integr Comp Physiol
. 2024 Feb;
326(5):R416-R426.
PMID: 38406845
Cerebrovascular reactivity (CVR) decreases with advancing age, contributing to increased risk of cognitive impairment; however, the mechanisms underlying the age-related decrease in CVR are incompletely understood. Age-related changes to T...
8.
Tummala S, Kuczmarski A, Del Vecchio A, Schwab A, Edwards D, Wenner M
Am J Physiol Heart Circ Physiol
. 2023 Nov;
326(1):H110-H115.
PMID: 37921661
Changes in endothelial function precede the development of cardiovascular disease (CVD). We have previously shown that age-related declines in endothelial function in women are due in part to a reduction...
9.
Hoopes E, Witman M, Dagata M, Brewer B, Edwards D, Robson S, et al.
J Am Heart Assoc
. 2023 Sep;
12(19):e029662.
PMID: 37776217
Background Day-to-day variability in sleep patterns and eating timing may disrupt circadian rhythms and has been linked with various adverse cardiometabolic outcomes. However, the extent to which variability in sleep...
10.
Kirkman D, Stock J, Shenouda N, Bohmke N, Kim Y, Kidd J, et al.
Am J Physiol Renal Physiol
. 2023 Aug;
325(4):F448-F456.
PMID: 37560769
Mitochondria-derived oxidative stress has been implicated in vascular and skeletal muscle abnormalities in chronic kidney disease (CKD). The purpose of this study was to investigate the effects of a mitochondria-targeted...