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Christopher R Martens

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Articles 38
Citations 962
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Recent Articles
1.
Twohy K, Kramer M, Diano A, Bailey O, Delgorio P, McIlvain G, et al.
Hum Brain Mapp . 2025 Feb; 46(2):e70147. PMID: 39916406
Aging and neurodegeneration impact structural brain integrity and can result in changes to behavior and cognition. Personality, a relatively stable trait in adults as compared to behavior, in part relies...
2.
DeConne T, Buckley D, Trott D, Martens C
Am J Physiol Heart Circ Physiol . 2024 Oct; 327(6):H1345-H1360. PMID: 39423035
Vascular dysfunction has emerged as a significant risk factor for the development of cardio- and cerebrovascular diseases (CVDs), which are currently the leading cause of morbidity and mortality worldwide. T...
3.
Decker K, Sanjana F, Rizzi N, Kramer M, Cerjanic A, Johnson C, et al.
Front Physiol . 2024 Oct; 15:1437973. PMID: 39416381
Objectives: To assess the reliability and validity of measuring resting cerebral blood flow (CBF) and hippocampal CBF using a single-post-labeling delay (PLD) and a multi-PLD pseudo-continuous arterial spin labeling (pCASL)...
4.
McDermott M, Martens C, Domanchuk K, Zhang D, Peek C, Criqui M, et al.
Nat Commun . 2024 Aug; 15(1):6890. PMID: 39134546
No abstract available.
5.
McDermott M, Martens C, Domanchuk K, Zhang D, Peek C, Criqui M, et al.
Nat Commun . 2024 Jun; 15(1):5046. PMID: 38871717
People with lower extremity peripheral artery disease (PAD) have increased oxidative stress, impaired mitochondrial activity, and poor walking performance. NAD+ reduces oxidative stress and is an essential cofactor for mitochondrial...
6.
DeConne T, Fancher I, Edwards D, Trott D, Martens C
Am J Physiol Regul Integr Comp Physiol . 2024 Feb; 326(5):R416-R426. PMID: 38406845
Cerebrovascular reactivity (CVR) decreases with advancing age, contributing to increased risk of cognitive impairment; however, the mechanisms underlying the age-related decrease in CVR are incompletely understood. Age-related changes to T...
7.
Stock J, Shenouda N, Chouramanis N, Patik J, Martens C, Farquhar W, et al.
Am J Physiol Heart Circ Physiol . 2023 Jul; 325(4):H617-H628. PMID: 37477688
Aging increases arterial stiffness and wave reflections that augment left ventricular wasted pressure effort (WPE). A single bout of exercise may be effective at acutely reducing WPE via reductions in...
8.
Sanjana F, Delgorio P, DeConne T, Hiscox L, Pohlig R, Johnson C, et al.
J Cereb Blood Flow Metab . 2023 Jul; 43(11):1931-1941. PMID: 37395479
Arterial stiffness and cerebrovascular pulsatility are non-traditional risk factors of Alzheimer's disease. However, there is a gap in understanding the earliest mechanisms that link these vascular determinants to brain aging....
9.
Freeberg K, Udovich C, Martens C, Seals D, Craighead D
J Gerontol A Biol Sci Med Sci . 2023 Apr; 78(12):2435-2448. PMID: 37068054
Advancing age and many disease states are associated with declines in nicotinamide adenine dinucleotide (NAD+) levels. Preclinical studies suggest that boosting NAD+ abundance with precursor compounds, such as nicotinamide riboside...
10.
Tinney E, Loui P, Raine L, Hiscox L, Delgorio P, Kramer M, et al.
Psychophysiology . 2023 Apr; 60(9):e14306. PMID: 37038273
Mild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease, is characterized by decreased memory and cognition, which are linked to degenerative changes in the brain. To assess whether white...