David G Brownstein
Overview
Explore the profile of David G Brownstein including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
571
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Recent Articles
1.
Jones F, Bailey M, Murray L, Lu Y, McNeilly S, Schlotzer-Schrehardt U, et al.
Dis Model Mech
. 2016 Feb;
9(2):165-76.
PMID: 26839400
Collagen IV is a major component of basement membranes, and mutations in COL4A1, which encodes collagen IV alpha chain 1, cause a multisystemic disease encompassing cerebrovascular, eye and kidney defects....
2.
Rog-Zielinska E, Thomson A, Kenyon C, Brownstein D, Moran C, Szumska D, et al.
Hum Mol Genet
. 2013 Apr;
22(16):3269-82.
PMID: 23595884
Glucocorticoids are vital for the structural and functional maturation of foetal organs, yet excessive foetal exposure is detrimental to adult cardiovascular health. To elucidate the role of glucocorticoid signalling in...
3.
Coutinho A, Brown J, Yang F, Brownstein D, Gray M, Seckl J, et al.
PLoS One
. 2013 Jan;
8(1):e54640.
PMID: 23349944
Mast cells are key initiators of allergic, anaphylactic and inflammatory reactions, producing mediators that affect vascular permeability, angiogenesis and fibrosis. Glucocorticoid pharmacotherapy reduces mast cell number, maturation and activation but...
4.
Coutinho A, Gray M, Brownstein D, Salter D, Sawatzky D, Clay S, et al.
Endocrinology
. 2011 Nov;
153(1):234-40.
PMID: 22067318
Glucocorticoids profoundly influence immune responses, and synthetic glucocorticoids are widely used clinically for their potent antiinflammatory effects. Endogenous glucocorticoid action is modulated by the two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD)....
5.
Deuchar G, McLean D, Hadoke P, Brownstein D, Webb D, Mullins J, et al.
Endocrinology
. 2010 Nov;
152(1):236-246.
PMID: 21106873
Mineralocorticoid receptor (MR) activation is proinflammatory and proatherogenic. Antagonism of MR improves survival in humans with congestive heart failure caused by atherosclerotic disease. In animal models, activation of MR exacerbates...
6.
Fraga Veloso G, Ohad D, Francis A, Vaughan J, Brownstein D, Culshaw G, et al.
Vet J
. 2010 Jun;
188(3):318-24.
PMID: 20554462
Urocortin (Ucn) peptides are the endogenous ligands for the corticotropin-releasing factor type 2 receptor (CRFR2). They have potentially important roles in cardiovascular physiology in health and disease, and show promise...
7.
Selfridge J, Song L, Brownstein D, Melton D
DNA Repair (Amst)
. 2010 Apr;
9(6):653-60.
PMID: 20362516
The Ercc1 gene is essential for nucleotide excision repair and is also important in recombination repair and the repair of interstrand crosslinks. We have previously used a floxed Ercc1 allele...
8.
Van Agtmael T, Bailey M, Schlotzer-Schrehardt U, Craigie E, Jackson I, Brownstein D, et al.
Hum Mol Genet
. 2010 Jan;
19(6):1119-28.
PMID: 20056676
Collagen type IV is the major structural component of the basement membrane and COL4A1 mutations cause adult small vessel disease, familial porencephaly and hereditary angiopathy with nephropathy aneurysm and cramps...
9.
Wishart T, Brownstein D, Thomson D, Tabakova A, Boothe K, Tsao J, et al.
BMC Neurosci
. 2009 Dec;
10:148.
PMID: 20015399
Background: The slow Wallerian Degeneration (Wld(S)) gene specifically protects axonal and synaptic compartments of neurons from a wide variety of degeneration-inducing stimuli, including; traumatic injury, Parkinson's disease, demyelinating neuropathies, some...
10.
Lawrence N, Song L, Doig J, Ritchie A, Brownstein D, Melton D
DNA Repair (Amst)
. 2009 Mar;
8(5):664-71.
PMID: 19264557
Topical application of thymidine dinucleotides (pTpT) provides some protection against the effects of UV on the skin, however, many details of the protective mechanism have yet to be elucidated. We...