Paul S Devenney
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Explore the profile of Paul S Devenney including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
1043
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Recent Articles
1.
Crichton J, Dunce J, Dunne O, Salmon L, Devenney P, Lawson J, et al.
Nat Struct Mol Biol
. 2023 Jan;
30(2):188-199.
PMID: 36635604
In meiosis, a supramolecular protein structure, the synaptonemal complex (SC), assembles between homologous chromosomes to facilitate their recombination. Mammalian SC formation is thought to involve hierarchical zipper-like assembly of an...
2.
Crane-Smith Z, Schoenebeck J, Graham K, Devenney P, Rose L, Ditzell M, et al.
Front Cell Dev Biol
. 2021 Apr;
9:595744.
PMID: 33869166
Enhancers that are conserved deep in evolutionary time regulate characteristics held in common across taxonomic classes. Here, deletion of the highly conserved enhancer SBE2 ( brain enhancer 2) in mouse...
3.
Williamson I, Kane L, Devenney P, Flyamer I, Anderson E, Kilanowski F, et al.
Development
. 2019 Sep;
146(19).
PMID: 31511252
Topologically associating domains (TADs) have been proposed to both guide and constrain enhancer activity. is located within a TAD known to contain all its enhancers. To investigate the importance of...
4.
Mackenzie K, Carroll P, Lettice L, Tarnauskaite Z, Reddy K, Dix F, et al.
EMBO J
. 2016 Feb;
35(8):831-44.
PMID: 26903602
Aicardi-Goutières syndrome (AGS) provides a monogenic model of nucleic acid-mediated inflammation relevant to the pathogenesis of systemic autoimmunity. Mutations that impair ribonuclease (RNase) H2 enzyme function are the most frequent...
5.
Anderson E, Devenney P, Hill R, Lettice L
Development
. 2014 Sep;
141(20):3934-43.
PMID: 25252942
Coordinated gene expression controlled by long-distance enhancers is orchestrated by DNA regulatory sequences involving transcription factors and layers of control mechanisms. The Shh gene and well-established regulators are an example...
6.
Lettice L, Williamson I, Devenney P, Kilanowski F, Dorin J, Hill R
Development
. 2014 Apr;
141(8):1715-25.
PMID: 24715461
Conservation within intergenic DNA often highlights regulatory elements that control gene expression from a long range. How conservation within a single element relates to regulatory information and how internal composition...
7.
A universal vector for high-efficiency multi-fragment recombineering of BACs and knock-in constructs
Dolt K, Lawrence M, Miller-Hodges E, Slight J, Thornburn A, Devenney P, et al.
PLoS One
. 2013 May;
8(4):e62054.
PMID: 23637962
There is an increasing need for more efficient generation of transgenic constructs. Here we present a universal multi-site Gateway vector for use in recombineering reactions. Using transgenic mouse models, we...
8.
Reijns M, Rabe B, Rigby R, Mill P, Astell K, Lettice L, et al.
Cell
. 2012 May;
149(5):1008-22.
PMID: 22579044
The presence of ribonucleotides in genomic DNA is undesirable given their increased susceptibility to hydrolysis. Ribonuclease (RNase) H enzymes that recognize and process such embedded ribonucleotides are present in all...
9.
Lettice L, Williamson I, Wiltshire J, Peluso S, Devenney P, Hill A, et al.
Dev Cell
. 2012 Feb;
22(2):459-67.
PMID: 22340503
Sonic hedgehog (Shh) expression during limb development is crucial for specifying the identity and number of digits. The spatial pattern of Shh expression is restricted to a region called the...
10.
Lettice L, Daniels S, Sweeney E, Venkataraman S, Devenney P, Gautier P, et al.
Hum Mutat
. 2011 Sep;
32(12):1492-9.
PMID: 21948517
Disruption of the long-range cis-regulation of developmental gene expression is increasingly recognized as a cause of human disease. Here, we report a novel type of long-range cis-regulatory mutation, in which...