David Frescas
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Explore the profile of David Frescas including associated specialties, affiliations and a list of published articles.
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17
Citations
1826
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Recent Articles
1.
Hall B, Gleiberman A, Strom E, Krasnov P, Frescas D, Vujcic S, et al.
Aging Cell
. 2020 Aug;
19(10):e13219.
PMID: 32856419
Adipose tissue is recognized as a major source of systemic inflammation with age, driving age-related tissue dysfunction and pathogenesis. Macrophages (Mφ) are central to these changes yet adipose tissue Mφ...
2.
Takai K, Kibe T, Donigian J, Frescas D, de Lange T
Mol Cell
. 2017 Jul;
67(1):162.
PMID: 28686874
No abstract available.
3.
Frescas D, Hall B, Strom E, Virtuoso L, Gupta M, Gleiberman A, et al.
Cell Cycle
. 2017 Jun;
16(16):1526-1533.
PMID: 28650766
Age-related health decline has been attributed to the accumulation of senescent cells recognized in vivo by p16(Ink4a) expression. The pharmacological elimination of p16(Ink4a)-positive cells from the tissues of mice was...
4.
Frescas D, Roux C, Aygun-Sunar S, Gleiberman A, Krasnov P, Kurnasov O, et al.
Proc Natl Acad Sci U S A
. 2017 Feb;
114(9):E1668-E1677.
PMID: 28193858
Studying the phenomenon of cellular senescence has been hindered by the lack of senescence-specific markers. As such, detection of proteins informally associated with senescence accompanies the use of senescence-associated β-galactosidase...
5.
Pu J, Frescas D, Zhang B, Feng J
Exp Biol Med (Maywood)
. 2015 May;
240(8):1065-70.
PMID: 25956682
The capability to modify the genome precisely and efficiently offers an extremely useful tool for biomedical research. Recent developments in genome editing technologies such as transcription activator-like effector nuclease and...
6.
Binding of TPP1 protein to TIN2 protein is required for POT1a,b protein-mediated telomere protection
Frescas D, de Lange T
J Biol Chem
. 2014 Jul;
289(35):24180-7.
PMID: 25056954
The single-stranded DNA binding proteins in mouse shelterin, POT1a and POT1b, accumulate at telomeres as heterodimers with TPP1, which binds TIN2 and thus links the TPP1/POT1 dimers with TRF1 and...
7.
Frescas D, de Lange T
Mol Cell Biol
. 2014 Jan;
34(7):1349-62.
PMID: 24469404
The shelterin protein TIN2 is required for the telomeric accumulation of TPP1/POT1 heterodimers and for the protection of telomeres by the POT1 proteins (POT1a and POT1b in the mouse). TIN2...
8.
Frescas D, de Lange T
Genes Dev
. 2014 Jan;
28(2):153-66.
PMID: 24449270
The progressive bone marrow failure syndrome dyskeratosis congenita (DC) is often caused by mutations in telomerase or the factors involved in telomerase biogenesis and trafficking. However, a subset of DC...
9.
Takai K, Kibe T, Donigian J, Frescas D, de Lange T
Mol Cell
. 2011 Nov;
44(4):647-59.
PMID: 22099311
To prevent ATR activation, telomeres deploy the single-stranded DNA binding activity of TPP1/POT1a. POT1a blocks the binding of RPA to telomeres, suggesting that ATR is repressed through RPA exclusion. However,...
10.
Frescas D, Guardavaccaro D, Kuchay S, Kato H, Poleshko A, Basrur V, et al.
Cell Cycle
. 2008 Nov;
7(22):3539-47.
PMID: 19001877
Heterochromatin plays an essential role in the preservation of epigenetic information, the transcriptional repression of repetitive DNA elements and inactive genes, and the proper segregation of chromosomes during mitosis. Here...