David F Bruhn
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Explore the profile of David F Bruhn including associated specialties, affiliations and a list of published articles.
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25
Citations
321
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Recent Articles
1.
Han J, Bruhn D, Childs C, Moreno Y, Salim A, Wu T, et al.
Antibiotics (Basel)
. 2025 Jan;
13(12.
PMID: 39766612
Background/objectives: There is an urgent need for new and improved anthelmintics that are not constrained by existing resistance pathways and that can safeguard the health and welfare of animals. Methods:...
2.
Han J, Bruhn D, Roberts D, Burkman E, Moreno Y, Salim A, et al.
J Nat Prod
. 2024 Nov;
87(12):2810-2821.
PMID: 39589926
A bioassay-guided chemical investigation of an Australian pasture-soil-derived sp. yielded the rare carbocyclic -polyketide kendomycin () along with a series of new analogues, goondomycins A-H (-), featuring unprecedented carbo/heterocyclic scaffolds...
3.
Han J, Bruhn D, Roberts D, Burkman E, Moreno Y, Bernhardt P, et al.
J Nat Prod
. 2024 Nov;
87(12):2855-2862.
PMID: 39582162
A chemical investigation of the Australian pasture soil-derived sp. S4S-00245B09, supported by chemical, bioactivity and cultivation profiling, yielded a new class of terpenyl-quinolin-4(1)-ones, goondolinones A and B ( and ),...
4.
Jin S, Bruhn D, Childs C, Burkman E, Moreno Y, Salim A, et al.
Antibiotics (Basel)
. 2024 Oct;
13(10).
PMID: 39452255
An investigation of ×19 soil samples collected under the auspices of the Australian citizen science initiative, Soils for Science, returned ×559 chemically dereplicated microbial isolates, of which ×54 exhibited noteworthy...
5.
Wu T, Hussein W, Samarasekera K, Zhu Y, Khalil Z, Jin S, et al.
Mar Drugs
. 2024 Jul;
22(7).
PMID: 39057421
A bioassay-guided chemical investigation of a bacterium, sp. CMB-MRB032, isolated from sheep feces collected near Bathurst, Victoria, Australia, yielded the known polyketide antimycins A4a () and A2a () as potent...
6.
Buzy A, Allain C, Harrington J, Lesuisse D, Mikol V, Bruhn D, et al.
ACS Omega
. 2021 May;
6(15):10288-10305.
PMID: 34056183
The nematode (the barber's pole worm) is an endoparasite infecting wild and domesticated ruminants worldwide. Widespread anthelmintic resistance of requires alternative strategies to control this parasite. Neuropeptide signaling represents a...
7.
Iverson A, Meyer C, Vogel P, Waidyarachchi S, Das N, Bruhn D, et al.
Antimicrob Agents Chemother
. 2019 Mar;
63(5).
PMID: 30858215
The most frequent ailment for which antibiotics are prescribed is otitis media (ear infections), which is most commonly caused by , , and Treatment of otitis media is complicated by...
8.
Zhang M, Prior A, Maddox M, Shen W, Hevener K, Bruhn D, et al.
ACS Omega
. 2019 Jan;
3(12):18343-18360.
PMID: 30613820
A series of novel chalcone and thiol-Michael addition analogues was synthesized and tested against and other clinically significant bacterial pathogens. Previously reported chalcone-like antibacterials (- and ) were used as...
9.
Liu J, Bruhn D, Lee R, Zheng Z, Janusic T, Scherbakov D, et al.
ACS Infect Dis
. 2017 Jan;
3(1):72-88.
PMID: 28081607
Spectinamides are a novel class of antitubercular agents with the potential to treat drug-resistant tuberculosis infections. Their antitubercular activity is derived from both ribosomal affinity and their ability to overcome...
10.
Robertson G, Scherman M, Bruhn D, Liu J, Hastings C, McNeil M, et al.
J Antimicrob Chemother
. 2016 Dec;
72(3):770-777.
PMID: 27999020
Objectives: New drug regimens employing combinations of existing and experimental antimicrobial agents are needed to shorten treatment of tuberculosis (TB) in humans. The spectinamides are narrow-spectrum semisynthetic analogues of spectinomycin,...