David E Symer
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Explore the profile of David E Symer including associated specialties, affiliations and a list of published articles.
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32
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1741
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Recent Articles
1.
Qin L, Moreno Rueda L, Ray U, Mahmud I, Tan L, Lorenzi P, et al.
Blood
. 2025 Feb;
PMID: 39912779
Plasma cell dyscrasias encompass a spectrum from the precursors monoclonal gammopathy of undetermined significance and smoldering myeloma to symptomatic myeloma, but the genes that enable progression and confer poor prognosis...
2.
Moreno Rueda L, Wang H, Akagi K, Dang M, Vora A, Qin L, et al.
Cell Rep Med
. 2025 Jan;
6(2):101925.
PMID: 39855192
Multiple myeloma is a clonal plasma cell (PC) dyscrasia that arises from precursors and has been studied utilizing approaches focused on CD138 cells. By combining single-cell RNA sequencing (scRNA-seq) with...
3.
Setayesh S, Ndacayisaba L, Rappard K, Hennes V, Moreno Rueda L, Tang G, et al.
NPJ Precis Oncol
. 2023 Sep;
7(1):95.
PMID: 37723227
Multiple myeloma (MM) is accompanied by alterations to the normal plasma cell (PC) proteome, leading to changes to the tumor microenvironment and disease progression. There is a great need for...
4.
Dang M, Wang R, Lee H, Patel K, Becnel M, Han G, et al.
Cancer Cell
. 2023 Jun;
41(6):1032-1047.e4.
PMID: 37311413
Multiple myeloma remains an incurable disease, and the cellular and molecular evolution from precursor conditions, including monoclonal gammopathy of undetermined significance and smoldering multiple myeloma, is incompletely understood. Here, we...
5.
Xi Y, Negrao M, Akagi K, Xiao W, Jiang B, Warner S, et al.
Oral Oncol
. 2023 Apr;
140:106372.
PMID: 37004423
Objectives: Somatic mutations may predict prognosis, therapeutic response, or cancer progression. We evaluated targeted sequencing of oral rinse samples (ORS) for non-invasive mutational profiling of oral squamous cell carcinomas (OSCC)....
6.
Akagi K, Symer D, Mahmoud M, Jiang B, Goodwin S, Wangsa D, et al.
Cancer Discov
. 2023 Jan;
13(4):910-927.
PMID: 36715691
Significance: Long-read sequencing of HPV-positive cancers revealed "heterocateny," a previously unreported form of genomic structural variation characterized by heterogeneous, interrelated, and repetitive genomic rearrangements within a tumor. Heterocateny is driven...
7.
Symer D, Akagi K, Geiger H, Song Y, Li G, Emde A, et al.
Genome Res
. 2021 Dec;
32(1):55-70.
PMID: 34903527
Human papillomavirus (HPV) causes 5% of all cancers and frequently integrates into host chromosomes. The HPV oncoproteins E6 and E7 are necessary but insufficient for cancer formation, indicating that additional...
8.
Broutian T, Jiang B, Li J, Akagi K, Gui S, Zhou Z, et al.
Cancer Lett
. 2020 Jan;
476:23-33.
PMID: 31958486
Human papillomavirus (HPV) insertions in cancer genomes have been linked to various forms of focal genomic instability and altered expression of neighboring genes. Here we tested the hypothesis that investigation...
9.
Wang Y, Liyanarachchi S, Miller K, Nieminen T, Comiskey Jr D, Li W, et al.
Thyroid
. 2019 Apr;
29(7):946-955.
PMID: 30957677
Familial non-medullary thyroid cancer (NMTC) accounts for a relatively small proportion of thyroid cancer cases, but it displays strong genetic predisposition. So far, only a few NMTC susceptible genes and...
10.
Gillison M, Akagi K, Xiao W, Jiang B, Pickard R, Li J, et al.
Genome Res
. 2018 Dec;
29(1):1-17.
PMID: 30563911
Human papillomavirus (HPV) is a necessary but insufficient cause of a subset of oral squamous cell carcinomas (OSCCs) that is increasing markedly in frequency. To identify contributory, secondary genetic alterations...