David E Housman
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Explore the profile of David E Housman including associated specialties, affiliations and a list of published articles.
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74
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4225
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Recent Articles
1.
Kang B, Murphy M, Ng C, Leventhal M, Huynh N, Im E, et al.
bioRxiv
. 2025 Mar;
PMID: 40027702
Genomic screens and GWAS are powerful tools for identifying disease-modifying genes, but it is often challenging to understand the pathways by which these genes function. Here, we take an integrated...
2.
Paryani F, Kwon J, Ng C, Jakubiak K, Madden N, Ofori K, et al.
Nat Commun
. 2024 Aug;
15(1):6742.
PMID: 39112488
The mechanisms underlying the selective regional vulnerability to neurodegeneration in Huntington's disease (HD) have not been fully defined. To explore the role of astrocytes in this phenomenon, we used single-nucleus...
3.
Fote G, Eapen V, Lim R, Yu C, Salazar L, McClure N, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(32):e2319091121.
PMID: 39074279
Understanding the normal function of the Huntingtin (HTT) protein is of significance in the design and implementation of therapeutic strategies for Huntington's disease (HD). Expansion of the CAG repeat in...
4.
Ferraro G, Ali A, Luengo A, Kodack D, Deik A, Abbott K, et al.
Nat Cancer
. 2022 Feb;
2(11):1243.
PMID: 35122065
No abstract available.
5.
Crittenden J, Zhai S, Sauvage M, Kitsukawa T, Burguiere E, Thomsen M, et al.
Neurobiol Dis
. 2021 Aug;
158:105473.
PMID: 34371144
CalDAG-GEFI (CDGI) is a protein highly enriched in the striatum, particularly in the principal spiny projection neurons (SPNs). CDGI is strongly down-regulated in two hyperkinetic conditions related to striatal dysfunction:...
6.
Ferraro G, Ali A, Luengo A, Kodack D, Deik A, Abbott K, et al.
Nat Cancer
. 2021 Jun;
2(4):414-428.
PMID: 34179825
Brain metastases are refractory to therapies that control systemic disease in patients with human epidermal growth factor receptor 2 (HER2+) breast cancer, and the brain microenvironment contributes to this therapy...
7.
Crittenden J, Gipson T, Smith A, Bowden H, Yildirim F, Fischer K, et al.
Eur J Neurosci
. 2021 Mar;
53(8):2450-2468.
PMID: 33759265
Disruptive or excessive repetitive motor patterns (stereotypies) are cardinal symptoms in numerous neuropsychiatric disorders. Stereotypies are also evoked by psychomotor stimulants such as amphetamine. The acquisition of motor sequences is...
8.
Drosu N, Edelman E, Housman D
Proc Natl Acad Sci U S A
. 2020 May;
117(22):12368-12374.
PMID: 32409608
Epstein-Barr virus (EBV) is a ubiquitous human γ-herpesvirus that establishes life-long infection and increases the risk for the development of several cancers and autoimmune diseases. The mechanisms by which chronic...
9.
Yildirim F, Ng C, Kappes V, Ehrenberger T, Rigby S, Stivanello V, et al.
Proc Natl Acad Sci U S A
. 2019 Nov;
116(49):24840-24851.
PMID: 31744868
Huntington's disease (HD) is a chronic neurodegenerative disorder characterized by a late clinical onset despite ubiquitous expression of the mutant Huntingtin gene () from birth. Transcriptional dysregulation is a pivotal...
10.
Ochaba J, Fote G, Kachemov M, Thein S, Yeung S, Lau A, et al.
Proc Natl Acad Sci U S A
. 2019 May;
116(22):10952-10961.
PMID: 31088970
Neuroinflammation is an important contributor to neuronal pathology and death in neurodegenerative diseases and neuronal injury. Therapeutic interventions blocking the activity of the inflammatory kinase IKKβ, a key regulator of...