Leslie M Thompson
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Explore the profile of Leslie M Thompson including associated specialties, affiliations and a list of published articles.
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90
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Recent Articles
1.
Stocksdale J, Leventhal M, Lam S, Xu Y, Wang Y, Wang K, et al.
bioRxiv
. 2025 Mar;
PMID: 40060574
Huntington's Disease (HD) is caused by a CAG repeat expansion in the gene encoding Huntingtin (HTT . While normal HTT function appears impacted by the mutation, the specific pathways unique...
2.
Cui Y, Arnold F, Li J, Wu J, Wang D, Philippe J, et al.
Nat Genet
. 2025 Jan;
57(2):369-378.
PMID: 39809899
Tandem repeat (TR) size variation is implicated in ~50 neurological disorders, yet its impact on gene regulation in the human brain remains largely unknown. In the present study, we quantified...
3.
Nguyen T, Miramontes R, Chillon-Marinas C, Maimon R, Vazquez-Sanchez S, Lau A, et al.
Nat Neurosci
. 2025 Jan;
28(2):280-292.
PMID: 39762660
Huntington's disease (HD) is caused by a CAG repeat expansion in the HTT gene, leading to altered gene expression. However, the mechanisms leading to disrupted RNA processing in HD remain...
4.
Kachemov M, Vaibhav V, Smith C, Sundararaman N, Heath M, Pendlebury D, et al.
Brain
. 2024 Oct;
PMID: 39391934
Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat mutation in the Huntingtin (HTT) gene. The mutation impacts neuronal protein homeostasis and cortical/striatal circuitry. SUMOylation is...
5.
Pradhan S, Bush K, Zhang N, Pandita R, Tsai C, Smith C, et al.
bioRxiv
. 2024 Sep;
PMID: 39345557
Highlights: BRG1 recruits HTT and NHEJ components to transcriptionally active DSBs.HTT joins BRG1 and PNKP to efficiently repair transcription related DSBs in brain.Mutant HTT impairs the functional integrity of TC-NHEJ...
6.
Maiuri T, Bazan C, Harding R, Begeja N, Kam T, Byrne L, et al.
Proc Natl Acad Sci U S A
. 2024 Sep;
121(40):e2318098121.
PMID: 39331414
Huntington disease (HD) is a genetic neurodegenerative disease caused by cytosine, adenine, guanine (CAG) expansion in the () gene, translating to an expanded polyglutamine tract in the HTT protein. Age...
7.
Sheeler C, Labrada E, Duvick L, Thompson L, Zhang Y, Orr H, et al.
Neurobiol Dis
. 2024 Sep;
201():106673.
PMID: 39307401
Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited and lethal neurodegenerative disease caused by the abnormal expansion of CAG repeats in the ATAXIN-1 (ATXN1) gene. Pathological studies identified dysfunction...
8.
Fote G, Eapen V, Lim R, Yu C, Salazar L, McClure N, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(32):e2319091121.
PMID: 39074279
Understanding the normal function of the Huntingtin (HTT) protein is of significance in the design and implementation of therapeutic strategies for Huntington's disease (HD). Expansion of the CAG repeat in...
9.
Feringa F, Koppes-den Hertog S, Wang L, Derks R, Kruijff I, Erlebach L, et al.
bioRxiv
. 2024 Jul;
PMID: 39005258
Lipid changes in the brain have been implicated in many neurodegenerative diseases including Alzheimer's Disease (AD), Parkinson's disease and Amyotrophic Lateral Sclerosis. To facilitate comparative lipidomic research across brain-diseases we...
10.
DiFiglia M, Leavitt B, Macdonald D, Thompson L
J Huntingtons Dis
. 2024 Jul;
13(2):119-131.
PMID: 38968054
The field of Huntington's disease research covers many different scientific disciplines, from molecular biology all the way through to clinical practice, and as our understanding of the disease has progressed...